Results 91 to 100 of about 2,680 (197)

Developments for the Treatment of Invasive Infections Due to Multidrug-resistant Acinetobacter baumannii [PDF]

, 2019
Acinetobacter baumannii is a significant pathogen in healthcare settings (specifically prominent in healthcare- and ventilator-associated pneumonia) due primarily to its virulence and resistance to a wide variety of antimicrobial drug classes, including ...
Drew, Richard, Laurent, David, Wilson, Dustin   +2 more
core   +1 more source

Screening of the Pandemic Response Box library identified promising compound candidate drug combinations against extensively drug-resistant Acinetobacter baumannii [PDF]

Infections caused by antimicrobial-resistant Acinetobacter baumannii pose a significant threat to human health, particularly in the context of hospital-acquired infections. As existing antibiotics lose efficacy against Acinetobacter isolates, there is an
Boonyalai, Nonlawat, Demons, Samandra T., Griesenbeck, John S., Lurchachaiwong, Woradee, Oransathid, Wilawan, Oransathid, Wirote, Peerapongpaisarn, Dutsadee, Ruamsap, Nattaya, Thamnurak, Chatchadaporn, Vesely, Brian A., Waters, Norman C., Wongpatcharamongkol, Nantanat   +11 more
core   +2 more sources

Management of vancomycin‐resistant Enterococci and daptomycin‐resistant Enterococci infections in liver transplant recipients in a single academic center

Transplant Infectious Disease, Volume 26, Issue 6, December 2024.
Vancomycin‐resistant Enterococci infections carry high mortality in liver transplant recipients, especially in the setting of daptomycin resistance. Infection relapsed or recurred in over 25% despite standard‐of‐care therapy. Source control is critical and more data is needed to establish an optimal treatment approach.
Aldo Barajas‐Ochoa, Olivia Hess, Tucker Smith, Matthew Ambrosio, Megan Morales, Idris Yakubu, Lora Thomas, David Bruno, Nicole Vissichelli   +8 more
wiley   +1 more source

Exploring the synthesis and biological properties of Tobramycin-Deferiprone hybrids against Pseudomonas aeruginosa [PDF]

, 2022
Tetracyclines and -lactam antibiotics are affected by multiple bacterial resistance mechanisms. One of the major resistance pathways is the alteration of the outer membrane and porin channels that prevent the entry of antibiotics into the periplasmic ...
Gandhi, Karan
core   +1 more source

Photosensitizer‐Amplified Antimicrobial Materials for Broad‐Spectrum Ablation of Resistant Pathogens in Ocular Infections

Advanced Materials, Volume 36, Issue 31, August 1, 2024.
A new class of photodynamic therapy agents combining nonphotosensitive and photosensitive benzodiazoles and their modular integration into peptide sequences for broad‐spectrum antimicrobial activity is presented. Chemical optimization leads to PEP3 with strong phototoxicity against Gram‐positive and Gram‐negative bacteria as well as fungi, including ...
Charles Lochenie, Sheelagh Duncan, Yanzi Zhou, Leonie Fingerhut, Alex Kiang, Sam Benson, Guanyu Jiang, Xiaogang Liu, Bethany Mills, Marc Vendrell   +9 more
wiley   +1 more source

Evaluation of Neisseria gonorrhoeae Isolates Susceptibility to Tetracycline Antibiotics from 9 Provinces in China Since 2020

Infection and Drug Resistance, 2022
Qian Zhou,1,2,* Wenqi Xu,1,2,* Xiaoyu Zhu,1,2 Jin Zhang,1,2 Yan Zhang,1,2 Yan Han,1,2 Kai Chen,1,2 Yueping Yin1,2 1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People’s Republic of China;
Zhou Q, Xu W, Zhu X, Zhang J, Zhang Y, Han Y, Chen K, Yin Y   +7 more
doaj  

AI‐driven drug discovery: Exploring Abaucin as a promising treatment against multidrug‐resistant Acinetobacter baumannii

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Background and Aims This study presents a comprehensive overview of a well‐recognized critical pathogen Acinetobacter baumannii and demonstrates the potential of artificial intelligence (AI) in discovering new antibiotics. It is well‐known for causing serious infections, especially in patients admitted to intensive care units, which is further
Roshanay E. Awan, Syeda Zainab, Fizza J. Yousuf, Sanila Mughal   +3 more
wiley   +1 more source

Antibacterial Activity of Eravacycline Against Carbapenem-Resistant Gram-Negative Isolates in China: An in vitro Study

Infection and Drug Resistance, 2023
Xuehan Zou,1,* Shaojun Jin,2,* Lingxia Chen,1,* Jie Li,1 Xiaofan Zhang,3 Hua Zhou,4 Xi Li,3 Haijun Huang1 1Center for General Practice Medicine, Department of Infectious Diseases, Zhejiang Provincial People’s Hospital, Affiliated People’s ...
Zou X, Jin S, Chen L, Li J, Zhang X, Zhou H, Li X, Huang H   +7 more
doaj  

Epidemiology and clinical significance of carbapenemases in Australia: a narrative review

Internal Medicine Journal, Volume 54, Issue 4, Page 535-544, April 2024.
Abstract Carbapenemase‐producing gram‐negative bacteria (CP‐GNB) infections threaten public health with high mortality, morbidity and treatment costs. Although frequencies remain low in Australia (total number of CP‐GNB infections reported was 907 in 2022), blaIMP‐4 has established low levels of endemicity in many states.
Abdullah Tarik Aslan, David L. Paterson
wiley   +1 more source

Antimicrobial consumption and resistance in bacteria from humans and food‐producing animals

EFSA Journal, Volume 22, Issue 2, February 2024.
Abstract The fourth joint inter‐agency report on integrated analysis of antimicrobial consumption (AMC) and the occurrence of antimicrobial resistance (AMR) in bacteria from humans and food‐producing animals (JIACRA) addressed data obtained by the Agencies' EU‐wide surveillance networks for 2019–2021.
European Centre for Disease Prevention and Control (ECDC), European Food Safety Authority (EFSA), European Medicines Agency (EMA)   +2 more
wiley   +1 more source