Results 171 to 180 of about 2,975,301 (351)

Legends to supplemental figures from Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells

, 2023
Xiaojia Niu, Jianyun Zhao, Jun Ma, Chengzhi Xie, Holly Edwards, Guan Wang, J. Timothy Caldwell, Shengyan Xiang, Xiaohong Zhang, Roland Chu, Zhihong J. Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge   +13 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Comprehensive Transcriptomic Analysis of the Molecular Mechanisms Conferring Resistance to Rice Blast in the Elite Restorer Line Fuhui2165 [PDF]

Shuijin Zhang, Yinyin Mao, Yonghe Hong, Feiyan Zheng, Rong‐Hua Hu, Sheng-Hung Tu, Fantao Zhang, Peng Zhou   +7 more
openalex   +1 more source

Data from Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer

, 2023
Alain R. Thierry, Brice Pastor, Zhi-Qin Jiang, Αναστασία Κατσιαμπούρα, Christine M. Parseghian, Jonathan M. Loree, Michael J. Overman, Cynthia Sánchez, Safia El Messaoudi, Marc Ychou, Scott Kopetz   +10 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i>. [PDF]

Antimicrob Agents Chemother
Funck T, McGowen K, Sullivan MR, Zinga S, Wolf ID, Nurjadi D, Denkinger CM, Rubin EJ.   +7 more
europepmc   +1 more source

Supplementary figure S1 from Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation

, 2023
Huai‐Qiang Ju, Takeshi Gocho, Mitzi Aguilar, Min Wu, Zhuonan Zhuang, Jie Fu, Katsuhiko Yanaga, Peng Huang, Paul J. Chiao   +8 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Reviewer #3 (Public Review): Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

Wanyoung Lim, Inwoo Hwang, Jiande Zhang, Zhenzhong Chen, Jeonghun Han, Jae‐Hyung Jeon, Bon‐Kyoung Koo, Sangmin Kim, Jeong Eon Lee, Youngkwan Kim, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Jee‐Yin Ahn, Sungsu Park   +14 more
openalex   +1 more source

Supplementary Methods, Figures S1-S10, and Table S1 from Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)

, 2023
Matthew Sung, Xingzhi Tan, Bingwen Lu, Jonathan Golas, Christine Hosselet, Fang Wang, Laurie Tylaska, Lindsay King, Dahui Zhou, Russell G. Dushin, Jeremy S. Myers, Edward Rosfjord, Judy Lucas, Hans‐Peter Gerber, Frank Loganzo   +14 more
openalex   +1 more source