Results 101 to 110 of about 1,415,742 (343)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Exercise interventions for adults and children with cerebral palsy (Protocol) [PDF]

open access: yes, 2015
This is the protocol for a review and there is no abstract. The objectives are as follows: - The primary aim of this systematic review is to evaluate the effect of exercise interventions on activity, participation, and health-related quality of life ...
Cassidy, EE   +3 more
core   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

open access: yesAging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth   +7 more
wiley   +1 more source

Cascade-targeting copper homeostasis nano-regulators for mild-photothermal boosted cuproptosis/ferroptosis mediated breast cancer therapy

open access: yesJournal of Nanobiotechnology
Inducing cuproptosis in tumor cells is significantly impeded by the challenges of arduous copper ion delivery in vivo and the unbreakable intracellular copper homeostasis, which leads to insufficient mitochondrial copper accumulation.
Xuejun Liang   +14 more
doaj   +1 more source

Effect of Concurrent Training with Different Order, Resistance and Endurance Training on Sphingosine-1-Phosphate in Slow and Fast Twitch Muscles in Wistar Rats

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2022
Background and Objective: Sphingosine-1-phosphate (S1P) plays an important role in muscle biology and is involved in hypertrophy and activation of satellite cells.
Maliheh Bagheri   +2 more
doaj  

Effectiveness of Resistance Circuit-Based Training for Maximum Oxygen Uptake and Upper-Body One-Repetition Maximum Improvements: A Systematic Review and Meta-Analysis. [PDF]

open access: yes, 2017
BACKGROUND: It is well known that concurrent increases in both maximal strength and aerobic capacity are associated with improvements in sports performance as well as overall health.
Alcaraz Ramón, Pedro Emilio   +3 more
core   +2 more sources

Translating a Preclinically Tested 15 Hz rTMS Protocol to Humans With Chronic Spinal Cord Injury: A Safety and Feasibility Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat   +8 more
wiley   +1 more source

Comparison of upper body strength gains between men and women after 10 weeks of resistance training [PDF]

open access: yes, 2016
Resistance training (RT) offers benefits to both men and women. However, the studies about the differences between men and women in response to an RT program are not conclusive and few data are available about upper body strength response.
Bottaro, Martim   +5 more
core   +4 more sources

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao   +5 more
wiley   +1 more source

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