Results 81 to 90 of about 1,415,742 (343)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Initial neuromuscular performance in older women influences response to explosive resistance training [PDF]

, 2009
The purpose of the study was to identify both demographic and neuromuscular traits that characterize successful or unsuccessful adaptation to resistance training in older women.
LaRoche, Dain P.
core   +1 more source

Imaginative Resistance and Modal Knowledge [PDF]

, 2020
Readers of fictions sometimes resist taking certain kinds of claims to be true according to those fictions, even when they appear explicitly or follow from applying ordinary principles of interpretation. This "imaginative resistance" is often taken to be
Nolan, Daniel
core  

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Resistance training might have improved insulin resistance by attenuating sarcopenia

Clinical Interventions in Aging, 2015
Yildiray Topcu,1 Fatih Tufan,2 M Akif Karan1 1Department of Geriatrics, Istanbul Faculty of Medicine, 2Department of Gerontology, Faculty of Medical Sciences, Istanbul University, Istanbul, TurkeyWe read the valuable article of Oliveira et al1 entitled &
Topcu Y, Tufan F, Karan MA
doaj  

Effects of variable resistance training with different load ratios on lower-limb strength and power in male college students

Journal of Exercise Science & Fitness
Objective: The optimum relationship combination of variable to constant resistance within variable resistance training (VRT) for enhancing lower-limb strength and power remains unclear.
Changbo Pan, Wei Li, Yuying Su, Yu Shi
doaj   +1 more source

The middle manager: Friend or foe of employee involvement [PDF]

, 1996
Middle management resistance has been frequently identified as a significant barrier to the success of employee involvement practices. This paper reviews evidence from the literature and from 12 case studies on the role played by middle managers in ...
Fenton-O'Creevy, Mark
core  

Ventilatory muscle strength, diaphragm thickness and pulmonary function in world-class powerlifters. [PDF]

, 2013
Resistance training activates the ventilatory muscles providing a stimulus similar to ventilatory muscle training. We examined the effects of elite powerlifting training upon ventilatory muscle strength, pulmonary function and diaphragm thickness in ...
AE Downey, AK McConnell, ATS/ERS, C Dunham, CH Huang, CJ Jolley, CL Gomez, DE Leith, EA Harman, F Al-Bilbeisi, FD McCool, FD McCool, Heather K. Venables, Hymsuen Liu, J Madanmohan, J Mandanmohan, JL Wait, JM Garcia-Manso, Julie T. de-Witt, LM Romer, LM Strongoli, Mark A. Faghy, MI Polkey, Michelle R. Brown, MR Miller, NS Arora, PD Wagner, Peter I. Brown, PH Quanjer, PI Brown, PI Brown, PI Brown, S Aznar-Lain, SH Wilson, SJ Enright, T Troosters, VA DePalo   +36 more
core   +2 more sources

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Lower-extremity resistance training on unstable surfaces improves proxies of muscle strength, power and balance in healthy older adults: a randomised control trial

BMC Geriatrics, 2016
Background It is well documented that both balance and resistance training have the potential to mitigate intrinsic fall risk factors in older adults. However, knowledge about the effects of simultaneously executed balance and resistance training (i.e ...
Nils Eckardt
doaj   +1 more source