Results 1 to 10 of about 1,033,768 (122)

Resistant and refractory migraine: clinical presentation, pathophysiology, and management [PDF]

EBioMedicine, 2023
Summary: Migraine is a leading cause of disability worldwide. A minority of individuals with migraine develop resistant or refractory conditions characterised by ≥ 8 monthly days of debilitating headaches and inadequate response, intolerance, or ...
Raffaele Ornello, Anna P. Andreou, Eleonora De Matteis, Tim P. Jürgens, Mia T. Minen, Simona Sacco   +5 more
doaj   +8 more sources

Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance [PDF]

The Journal of Headache and Pain, 2021
Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable ...
Simona Sacco, Christian Lampl, Antoinette Maassen van den Brink, Valeria Caponnetto, Mark Braschinsky, Anne Ducros, Patrick Little, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Paolo Martelletti, Zaza Katsarava, On behalf of the Burden and Attitude to Resistant and Refractory (BARR) Study Group   +14 more
doaj   +18 more sources

Editorial: Spotlight on resistant and refractory migraine

Frontiers in Neurology, 2023
Raffaele Ornello, Bianca Raffaelli
doaj   +6 more sources

European headache federation consensus on the definition of resistant and refractory migraine [PDF]

The Journal of Headache and Pain, 2020
Introduction Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments.
Simona Sacco, Mark Braschinsky, Anne Ducros, Christian Lampl, Patrick Little, Antoinette Maassen van den Brink, Patricia Pozo-Rosich, Uwe Reuter, Elena Ruiz de la Torre, Margarita Sanchez Del Rio, Alexandra J. Sinclair, Zaza Katsarava, Paolo Martelletti   +12 more
doaj   +11 more sources

Longitudinal assessment of migraine burden in resistant and refractory migraine – Data from the prospective REFINE study

The Journal of Headache and Pain
Background Some individuals with migraine fail to respond adequately to preventive treatments, bearing most of migraine burden. The European Headache Federation (EHF) classifies these individuals into resistant migraine (ResM) or refractory migraine ...
Umberto Pensato, Raffaele Ornello, Chiara Rosignoli, Valeria Caponnetto, Agnese Onofri, Mark Braschinsky, Olga Sved, Raquel Gil-Gouveia, Renato Oliveira, Christian Lampl, Jakob Paungarttner, Paolo Martelletti, William David Wells-Gatnik, Isabel Pavao Martins, Dimos D. Mitsikostas, Loukia Apostolakopoulou, Aynur Ozge, Dilan Bayar Narin, Patricia Pozo-Rosich, Albert Munoz-Vendrell, Maria Pia Prudenzano, Martino Gentile, Kristina Ryliskiene, Jurgita Vainauskiene, Margarita Sanchez-del-Rio, Fabrizio Vernieri, Gianmarco Iaccarino, Marta Waliszewska-Prosół, Sławomir Budrewicz, Marta Carnovali, Zaza Katsarava, Simona Sacco   +31 more
doaj   +5 more sources

Central sleep apnea in a treatment-resistant migraine patient: a case report [PDF]

Sleep Science, 2022
Introduction: Patients with migraine, who suffer from sleep apnea, whether obstructive or central, might lead to treatment-resistant headaches. In this study, we have reported a 42-year-old man with a confirmed treatment-resistant migraine headaches and ...
Zahra Parsapour, Erfan Torabi, Hamed Amirifard, Leila Emami   +3 more
doaj   +3 more sources

Treatment of resistant chronic migraine with anti-CGRP monoclonal antibodies: a systematic review

European Journal of Medical Research, 2022
Background Resistant chronic migraine is a highly disabling condition which is very difficult to treat. The majority of the treatments for migraine prophylaxis are nonspecific and present weak safety profiles, leading to low adherence and discontinuation.
Hugo Sevivas, Paula Fresco
doaj   +3 more sources

Refractory migraine

Неврология, нейропсихиатрия, психосоматика
Many patients with chronic migraine abuse symptomatic medications, have drug-induced headaches, psychiatric comorbidities and respond poorly to conventional preventive therapy.
G. R. Tabeeva, O. V. Kosivtsova, N. A. Kovalchuk, T. A. Orlyuk   +3 more
doaj   +3 more sources

Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats

The Journal of Headache and Pain
Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Filiz Onat, Hayrunnisa Bolay, Yildirim Sara   +5 more
doaj   +5 more sources

Long-term persistence of anti-calcitonin gene-related peptide monoclonal antibodies in treatment-resistant migraine: A three-year follow-up study in Spain

Cephalalgia Reports
Background and objective Migraine remains a therapeutic challenge, particularly in patients unresponsive to standard treatments. Although anti-calcitonin gene-related peptide (anti-CGRP) monoclonal antibodies (mAbs) represent a novel therapeutic option ...
Tania Garrido Hernández, Luis Alberto Andrade Zumarraga, Patricia Perea Justicia, Josefina Martínez Simón, Antonio Arjona Padillo   +4 more
doaj   +2 more sources