Results 151 to 160 of about 18,735 (188)
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Resistin is expressed in pancreatic islets
Biochemical and Biophysical Research Communications, 2003Resistin, a recently described adipocyte factor, is regulated by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. While resistin has been proposed to mediate insulin resistance in rodents, little is known about human resistin and its expression in pancreatic islets has not been tested.
Charles Vinson +2 more
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Science's STKE, 2004
Obesity is one of the most potent risk factors for insulin resistance and type 2 diabetes, but the molecular mechanisms underlying this link are poorly understood. The fat-derived hormone resistin has been postulated to be part of that mechanism, but its role in glucose homeostasis has been controversial. Banerjee et al.
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Obesity is one of the most potent risk factors for insulin resistance and type 2 diabetes, but the molecular mechanisms underlying this link are poorly understood. The fat-derived hormone resistin has been postulated to be part of that mechanism, but its role in glucose homeostasis has been controversial. Banerjee et al.
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Biochemical Genetics, 2015
Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine
Yamunah Devi, Apalasamy +7 more
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Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine
Yamunah Devi, Apalasamy +7 more
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An update on the biology and physiology of resistin
Cellular and Molecular Life Sciences, 2004Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function. Resistin is produced by white and brown adipose tissues but has also has been identified in several other tissues, including the hypothalamus, pituitary and adrenal glands, pancreas, gastrointestinal tract ...
Ernest Adeghate
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The potential role of resistin in atherogenesis
Atherosclerosis, 2005Resistin, an adipocyte-derived cytokine linked to insulin resistance and obesity, has recently been shown to activate endothelial cells (ECs). Using microarrays, we found that along with numerous other pro-atherosclerotic genes, resistin expression levels are elevated in the aortas of C57BL/6J apoE-/- mice; these findings led us to further explore the ...
Burnett MS +15 more
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The Role of Resistin in Inflammatory Myopathies
Current Rheumatology Reports, 2013Both immune and non-immune mechanisms are involved in muscle damage and dysfunction occurring in idiopathic inflammatory myopathies (IIMs). Crosstalk among inflammatory cells, muscle and endothelial cells is essential in the pathogenesis of IIMs. Resistin, originally described as an adipokine linking obesity and insulin resistance in rodents, has been ...
Mária, Filková +2 more
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Resistin: molecular history and prognosis
Journal of Molecular Medicine, 2003Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte
Ronadip R, Banerjee, Mitchell A, Lazar
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The role of resistin in colorectal cancer
Clinica Chimica Acta, 2012To date the role of resistin in colorectal cancer (CRC) is far from being elucidated. The aim of this study was to investigate the association between serum resistin levels and CRC in relation to known risk/protective factors including anthropometric, metabolic, inflammatory parameters as well as lifestyle individual characteristics.40 CRC patients and
Danese E. +8 more
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Transcriptional regulation of the resistin gene
Domestic Animal Endocrinology, 2006Resistin, which is a protein that is secreted exclusively by adipocytes, plays an important role in insulin resistance and adipocyte differentiation. Adipocytes express significant amounts of resistin mRNA, while preadipocytes express low levels of resistin mRNA. The mechanism that causes this difference is unclear.
Lei, Zhou +5 more
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Resistin and Postburn Insulin Dysfunction
Journal of Trauma: Injury, Infection & Critical Care, 2009Postburn insulin dysfunction is a significant contributor to morbidity and mortality. A satisfactory mechanism for explaining this phenomenon remains elusive; however, resistin has been postulated to be involved. Initially discovered as an insulin antagonist secreted from adipose tissue in murine models, resistin's function in humans has been more ...
Steve L, Duffy +3 more
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