Results 181 to 190 of about 5,034,272 (293)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Renal Resistive Index from Renal Hemodynamics to Cardiovascular Risk: Diagnostic, Prognostic, and Therapeutic Implications. [PDF]

Diseases
Geraci G, Ferrara P, La Via L, Sorce A, Calabrese V, Cuttone G, Paternò V, Pallotti F, Sambataro G, Zanoli L, George J, Polosa R, Mulè G, Carollo C.   +13 more
europepmc   +1 more source

Influence of arterial blood gases on the renal arterial resistive index in intensive care unit. [PDF]

J Transl Med, 2023
Ruiz S, Vardon-Bounes F, Virtos M, Seguin T, Crognier L, Rouget A, Georges B, Conil JM, Minville V.   +8 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Furosemide Stress Test and Renal Resistive Index for Prediction of Severity of Acute Kidney Injury in Sepsis. [PDF]

Cureus, 2023
Das PK, Maurya SK, Nath SS, Kumar T, Rao N, Shrivastava N.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The value of intrarenal resistive index in delayed graft function after kidney transplantation. [PDF]

Quant Imaging Med Surg
Guo Y, Yang Y, Luo S, Ren Y, Chen H, Yang Y, Shi S, Yang L, Li Y, Zhou J.   +9 more
europepmc   +1 more source

The Impact of COVID-19 on Renal Resistive Index in Kidney Transplant Recipients. [PDF]

Transplant Proc, 2023
Karaaslan M, Yılmaz M, Polat ME, Şirin ME, Ölçücüoğlu E, Ölçücüoğlu E.   +5 more
europepmc   +1 more source

Renal Resistive Index Predicts Postoperative Blood Pressure Outcome in Primary Aldosteronism

HYPERTENSION, 2016
Y. Iwakura, S. Ito, R. Morimoto, M. Kudo, Y. Ono, M. Nezu, K. Takase, K. Seiji, S. Ishidoya, Y. Arai, Yasuharu Funamizu, T. Miki, Yasuhiro Nakamura, H. Sasano, F. Satoh   +14 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source