Results 101 to 110 of about 145,637 (315)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Humidity dependent impedance of Zn(_x)Co(_2-x)GeO(_4) [PDF]

open access: yes, 1999
Zn(_x)Co(_2-x)GeO(_4) materials were prepared and the variation in structure with composition was investigated using XED, SEM and EDX analysis. Limited series of solid solution were identified at both ends of the compositional range.
Hales, Debbie
core  

Densification treatment and properties of carbon fiber reinforced contact strip

open access: yesScience and Engineering of Composite Materials, 2014
The high temperature caused by current-carrying wear could affect the thermal reliability of resin-based contact strip greatly. This study adopted liquid-phase impregnation-carbonization (IC) technique to improve the thermal stability and densification ...
Yuan Hua   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Gold nanoresistors with near-constant resistivity in the cryogenic-to-room temperature range

open access: yes, 2011
Using a multiple plasma deposition-annealing (MDA) technique, we have fabricated an Au nanoisland-based thin film nanoresistor with a very low temperature coefficient of electrical resistivity in a cryogenic-to-room temperature range of 10 to 300 K.
Ostrikov, K.   +5 more
core   +1 more source

Low frequency electric properties utilization in agriculture and food treatment

open access: yesResearch in Agricultural Engineering, 2003
Determination of electrical properties is utilized in a wide range of disciplines and industries. A brief compendium of agricultural materials and food electrical properties exploitation is presented in this paper.
Z. Hlaváčová
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Low Resistivity Transparent Conducting Oxide Thin Films Prepared by Pulsed Laser Deposition

open access: yes, 2004
P(論文)In a bid obtain resistivity of on the order of 10^ Ω・cm, we fabricated a series of transparent conducting films from indium tin oxide (ITO) and aluminum-doped zinc oxide (AZO) by pulsed laser deposition (PLD) using an ArF excimer laser (λ=193 nm ...
安倉, 秀明   +14 more
core  

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