Results 101 to 110 of about 176,276 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Development of electrical resistivity imaging methods for geological and archaeological prospecting [PDF]
, 1993 Not ...
Xu, Biwen
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Magnetochemistry, 2019 Magnetically responsive fluid based on polymers of natural rubber (NR-latex) involves a magnetic compound fluid (MCF) rubber liquid. For a wide range of engineering applications of suspensions or liquids with particles, their electrical characteristics ...
Kunio Shimada
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fast imaging techniques of marine controlled source electromagnetic (CSEM) data
, 2008 Obtaining information regarding the resistivity structure of the subsurfacefrom marine CSEM data involves complex processes. 1D and 2D forward and inversemodelling are currently the standard approaches used to produce geoelectrical models,with 3D ...
Morris, Edward C.
core +1 more source
Geo-electrical resistivity characterization of sedimentary rocks in dent peninsular, Lahad Datu, Sabah [PDF]
, 2013 A vertical electrical sounding (VES) survey was conducted in Dent Peninsular, Lahad Datu Sabah. The main objectives of the study are to determine the geo-electrical characteristic curves of the sediments and to relate them to various rock formations and ...
Abdul Rahim Samsudin, Hardianshah Saleh
core +2 more sources