Results 131 to 140 of about 145,637 (315)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Caracterização de microestruturas porosas a partir da análise de imagens digitais: permeabilidade intrínseca e fator de formação [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia MecânicaA caracterização de materiais porosos se constitui em um problema de grande interesse científico e tecnológico.
Gaspari, Henrique Cesar de
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Detection of graves using the micro-resistivity method

, 2006
This paper describes a case history of the application of resistivity methods on the detection of a tomb tentatively associated with Damião de Goes, a prominent Portuguese humanist who lived in the XVI century.
Matias, H. C., Machado, C., Luzio, R., Monteiro Santos, F. A., Rodrigues Ferreira, F. E.   +4 more
core  

Hierarchical multilevel arrays of self-assembled gold nanoparticles : Control of resistivity-temperature dependence

, 2010
The possibility to control the electric resistivity-temperature dependence of the nanosized resistive components made using hierarchical multilevel arrays of self-assembled gold nanoparticles prepared by multiple deposition/annealing is demonstrated.
Ostrikov, K., Han, Z.J., M. M. A. Yajadda, Yajadda, M.M.A., I. Levchenko, K. Ostrikov, Levchenko, I., Z. J. Han   +7 more
core   +1 more source

Quasi-3D Geoelectrical Imaging as A New Application for Landslide Investigations: A Tunnel Case Induced by Blasting Activity

JIF (Jurnal Ilmu Fisika)
Landslides are a significant hazard in mountainous regions, especially when influenced by construction activities such as tunnel excavation. In this paper, we aim to conduct a slope stability analysis as a result of tunnel blasts using quasi-3D ...
Rudi Cahyadi, Widodo
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Using resistivity or logarithm of resistivity to calculate depth of investigation index to assess reliability of electrical resistivity tomography

, 2017
We have conducted a comparative study to determine the most efficient and reliable way to calculate the depth of investigation (DOI) index to assess the quality of electrical resistivity tomography models.
Simon D. Carrière, Danquigny, Charles, Konstantinos Chalikakis, Carriere, Simon, Laura Torres-Rondon, Charles Danquigny, Chalikakis, Konstantinos, Torres-Rondon, Laura   +7 more
core   +1 more source