Results 171 to 180 of about 351,150 (284)

Resist resistance

This thesis explores changes in swallowing and communication following total laryngectomy (removal of the voice box). Chapter 1 outlines the anatomy and physiology of the pharynx and larynx, along with the functional changes that occur after the surgery.
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Physicochemical characteristics and mechanism analysis of loess at different high-temperature stages. [PDF]

Sci Rep
Bai H, Yin W, Li X, Qiao J, Tian C, Wang Y.   +5 more
europepmc   +1 more source

Resisting resistance to cancer immunotherapy [PDF]

Thoracic Cancer, 2018
Lam, Walter Sze‐Tung, Wang, Louis Zizhao, Roudi, Raheleh, Yong, Wei‐Peng, Syn, Nicholas L., Sundar, Raghav   +5 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Research on missing value prediction of measured ERT data for coal mine based on a GRNN algorithm. [PDF]

PLoS One
Wang P, Yi X, Wang S.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Experimental study on electrical dispersion in 3D printed resin cores reveals pore and fluid property mechanisms. [PDF]

Sci Rep
Shi H, Ke S, Zhang Y, Hu H, Luo H.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Bandwidth-tuned Mott transition and superconductivity in moiré WSe₂. [PDF]

Nature
Xia Y, Han Z, Zhu J, Zhang Y, Knüppel P, Watanabe K, Taniguchi T, Mak KF, Shan J.   +8 more
europepmc   +1 more source