Results 51 to 60 of about 3,605,424 (316)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Nature Communications, 2017 Light-sheet fluorescence microscopy enables high resolution imaging of biological samples. Here the authors use reflective coverslips to obtain multiple sample views simultaneously, improving the speed of acquisition and resolution compared to dual-view ...
Yicong Wu +13 more
doaj +1 more source
A European Deposit Insurance and Resolution Fund. CEPS Working Document No. 364, 10 May 2012 [PDF]
, 2012 The eurozone is caught in a ‘diabolical loop’ in which weak domestic banking systems damage sovereign fiscal positions and conversely, in which risky sovereign positions disproportionately threaten domestic banking stability.
Schoenmaker, Dirk, Gros, Daniel
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
«Soft power» as a catalysator of socio-political conflicts
RUDN Journal of Public Administration, 2019 The article is devoted to the study of a set of technologies united by the term soft power from the standpoint of using the potential of these technologies in order to manage socio-political conflicts in target countries.
Oleg Borisovich Ivanov
doaj +1 more source
Final report of the geothermal roundtable, April 1990, Center for Alternative Dispute Resolution [PDF]
, 1990 Discusses the roundtable meetings for Hawaii geothermal development on November 9, 1988 and February 23, 1989, the roundtable's subcommittee meeting on April 6, 1989, and the subgroup's meeting on December 6 ...
Center for Alternative Dispute Resolution
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Guiding Parents Through Separation:Family Matters - an innovative support service from Resolution [PDF]
, 2016 Resolution developed an innovative new service called Family Matters. It aimed to help separated parents collaborate more effectively in the best interests of their children and involved the services of a new type of practitioner – a ‘Family Matters ...
Foster, Ida, Skinner, Christine
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source