Results 61 to 70 of about 2,165,771 (247)

A Mathematical Note on the Evolutionary Competitiveness of the Trisexual Nematode Auanema Rhodensis

Journal of Mathematical Sciences and Modelling, 2020
Trisexual species with female, male and self-fertilizing hermaphrodite sub-populations are rather exceptions in nature. Though, certain nematode/ worm species, like Auanema Rhodensis, have evolved that way.
Florian Rupp
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Monomial Resolutions

Journal of Algebra, 2001
Let \(G\) be a finite group. In the paper under review, the author constructs a functor \(\mathcal F\) from the category \(\mathbb{C} G\)-mod of finitely generated \(\mathbb{C} G\)-modules to the homotopy category \({\mathcal K}^b(\mathbb{C} G\text{-mon})\) of bounded chain complexes in the category \(\mathbb{C} G\)-mon. The objects of \(\mathbb{C} G\)-
openaire   +2 more sources

“Resolution” in high-resolution electron microscopy [PDF]

Ultramicroscopy, 1992
Abstract In the field of high-resolution transmission electron microscopy (HRTEM), the term “resolution” has come to hold a number of different meanings [M.A. O'Keefe and J.C.H. Spence, in: Proc. 49th Annual EMSA Meeting, p. 498]. The present work reviews the various definitions of HRTEM resolution, derives theoretical expressions for resolution, and
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Multi-Agent RAG Framework for Entity Resolution: Advancing Beyond Single-LLM Approaches with Specialized Agent Coordination

Computers
Entity resolution in real-world datasets remains a persistent challenge, particularly for identifying households and detecting co-residence patterns within noisy and incomplete data.
Aatif Muhammad Althaf, Muzakkiruddin Ahmed Mohammed, Mariofanna Milanova, John Talburt, Mert Can Cakmak   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source