Results 231 to 240 of about 44,785 (315)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery. [PDF]

Inf inference
Landa B, Kluger Y.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Creating a novel algorithm for studying the strong convergence to a sequence with applications. [PDF]

PLoS One
Hammad HA, Dafaalla ME, Abdalla MEM.
europepmc   +1 more source

Wavelet-based resolvent analysis of non-stationary flows [PDF]

Eric Ballouz, Barbara Lopez-Doriga, Scott T. M. Dawson, H. Jane Bae   +3 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The geometry and dimensionality of brain-wide activity. [PDF]

Elife
Wang Z, Mai W, Chai Y, Qi K, Ren H, Shen C, Zhang S, Tan G, Hu Y, Wen Q.   +9 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Amyloïdose cutanée nodulaire localisée consécutive à des injections d’insuline chez une femme de 40 ans. [PDF]

CMAJ
Zhuang M, Vaziri M, Sandhu N.
europepmc   +1 more source

Spectral asymptotics for resolvent differences of elliptic operators with $\delta$ and $\delta^{\prime}$-interactions on hypersurfaces

, 2015
Jussi Behrndt, Gerd Grubb, Matthias Langer, Vladimir Lotoreichik   +3 more
openalex   +2 more sources