Results 51 to 60 of about 43,954 (320)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Box resolvability

open access: yesTopology and its Applications, 2016
We say that a topological group $G$ is partially box $ $-resolvable if there exist a dense subset $B$ of $G$ and a subset $A $ of $G$, $|A|= $ such that the subsets $\{ aB: a\in A\}$ are pairwise disjoint. If $G=AB$ then $G$ is called box $ $-resolvable. We prove two theorems. If a topological group $G$ contains an injective convergent sequence then
openaire   +2 more sources

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

A partial factorization of the powersum formula

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2004
For any univariate polynomial P whose coefficients lie in an ordinary differential field 𝔽 of characteristic zero, and for any constant indeterminate α, there exists a nonunique nonzero linear ordinary differential operator ℜ of finite order such that ...
John Michael Nahay
doaj   +1 more source

Resolvability vs. almost resolvability

open access: yesTopology and its Applications, 2009
A space X is kappa-resolvable (resp. almost kappa-resolvable) if it contains kappa dense sets that are pairwise disjoint (resp. almost disjoint over the ideal of nowhere dense subsets of X). Answering a problem raised by Juhasz, Soukup, and Szentmiklossy, and improving a consistency result of Comfort and Hu, we prove, in ZFC, that for every infinite ...
Juhász, István   +2 more
openaire   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Periodic solutions of Volterra integral equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1988
Consider the system of equationsx(t)=f(t)+∫−∞tk(t,s)x(s)ds,           (1)andx(t)=f(t)+∫−∞tk(t,s)g(s,x(s))ds.       (2)Existence of continuous periodic solutions of (1) is shown using the resolvent function of the kernel k.
M. N. Islam
doaj   +1 more source

Resolvent estimates with mild trapping

open access: yes, 2012
We discuss recent progress in understanding the effects of certain trapping geometries on cut-off resolvent estimates, and thus on the qualititative behavior of linear evolution equations.
Wunsch, Jared
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Electromagnetic fields calculation on the moving boundary of the medium irradiated by Airy pulse

open access: yesВісник Харківського національногоуніверситету імені В.Н. Каразіна. Серія: Радіофізика та електроніка
Relevance. The new effects of electromagnetic pulse propagation obtained as a result of its interaction with a moving boundary can be actively used when pulses pass through various devices and equipment, such as lenses, mirrors, etc.
O.V. Zhyla, N.P. Stognii
doaj   +1 more source

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