Results 101 to 110 of about 27,208 (276)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

An inverse problem for a second-order differential equation in a Banach space

Abstract and Applied Analysis, 2004
We consider the problem of determining the unknown term in the right-hand side of a second-order differential equation with unbounded operator generating a cosine operator function from the overspecified boundary data.
Y. Eidelman
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Semigroup Approach to Semilinear Partial Functional Differential Equations with Infinite Delay

Journal of Inequalities and Applications, 2007
We describe a semigroup of abstract semilinear functional differential equations with infinite delay by the use of the Crandall Liggett theorem. We suppose that the linear part is not necessarily densely defined but satisfies the resolvent estimates of ...
Hassane Bouzahir
doaj   +1 more source

Kernel-resolvent relations for an integral equation [PDF]

Tatra Mountains Mathematical Publications, 2011
Abstract We consider a scalar integral equation where |G(t,z)| ≤ ϕ(t)|z|, C is convex, and . Related to this is the linear equation and the resolvent equation . A Liapunov functional is constructed which gives qualitative results about all three equations. We have two goals.
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research on the Existence and Uniqueness of Solutions to Fractional Diffusion Equations with Three-Parameter Damping Terms

Axioms
This paper investigates a fractional diffusion equation incorporating a three-parameter damping. By employing a generalized Mittag–Leffler function alongside the associated Riemann–Liouville resolvent family, we establish the well-posedness of strong ...
Zhi-Chao Lu, Shi-You Lin, Ting-Ting Hu
doaj   +1 more source

Global existence and controllability to a stochastic integro-differential equation

Electronic Journal of Qualitative Theory of Differential Equations, 2010
In this paper, we are focused upon the global uniqueness results for a stochastic integro-differential equation in Fréchet spaces. The main results are proved by using the resolvent operators combined with a nonlinear alternative of Leray-Schauder type ...
Yong-Kui Chang, Zhi-Han Zhao, Juan Nieto
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source