Results 81 to 90 of about 27,208 (276)

Set-Valued Resolvent Equations and Mixed Variational Inequalities

Journal of Mathematical Analysis and Applications, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aslam, Noor Muhammad, Noor, Khalida Inayat, Rassias, Th. M.   +2 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Hill's equation for a homogeneous tree

Electronic Journal of Differential Equations, 1997
The analysis of Hill's operator $-D^2 + q(x)$ for $q$ even and periodic is extended from the real line to homogeneous trees ${cal T}$. Generalizing the classical problem, a detailed analysis of Hill's equation and its related operator theory on $L^2({cal
Robert Carlson
doaj  

Dirichlet problem for second-order abstract differential equations

Electronic Journal of Differential Equations, 2020
We study the well-posedness in the space of continuous functions of the Dirichlet boundary value problem for a homogeneous linear second-order differential equation u''+Au = 0, where A is a linear closed densely defined operator in a Banach space. We
Giovanni Dore
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Existence results for fractional neutral integro-differential systems with nonlocal condition through resolvent operators

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019
The manuscript is primarily concerned with the new existence results for fractional neutral integro-differential equation (FNIDE) with nonlocal conditions (NLCs) in Banach spaces.
Mallika D., Baleanu D., Suganya S., Arjunan M. Mallika   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

On the Convergence of the Yosida–Cayley Variational Inclusion Problem with the XOR Operation and Inertial Extrapolation Scheme

Mathematics
This article studies the structure and properties of real-ordered Hilbert spaces, highlighting the roles of the XOR and XNOR logical operators in conjunction with the Yosida and Cayley approximation operators.
Arifuzzaman, Syed Shakaib Irfan, Iqbal Ahmad   +2 more
doaj   +1 more source

Cutoff resolvent estimates and the semilinear Schrödinger equation [PDF]

Proceedings of the American Mathematical Society, 2008
This paper shows how abstract resolvent estimates imply local smoothing for solutions to the Schr dinger equation. If the resolvent estimate has a loss when compared to the optimal, non-trapping estimate, there is a corresponding loss in regularity in the local smoothing estimate.
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source