Results 61 to 70 of about 27,208 (276)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Periodic solutions of Volterra integral equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1988
Consider the system of equationsx(t)=f(t)+∫−∞tk(t,s)x(s)ds,           (1)andx(t)=f(t)+∫−∞tk(t,s)g(s,x(s))ds.       (2)Existence of continuous periodic solutions of (1) is shown using the resolvent function of the kernel k.
M. N. Islam
doaj   +1 more source

Stochastic Volterra equations driven by cylindrical Wiener process

open access: yes, 2007
In this paper, stochastic Volterra equations driven by cylindrical Wiener process in Hilbert space are investigated. Sufficient conditions for existence of strong solutions are given.
Karczewska, Anna, Lizama, Carlos
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Correctness conditions for high-order differential equations with unbounded coefficients

open access: yesBoundary Value Problems, 2021
We give some sufficient conditions for the existence and uniqueness of the solution of a higher-order linear differential equation with unbounded coefficients in the Hilbert space.
Kordan N. Ospanov
doaj   +1 more source

The resolvent of singular integral equations [PDF]

open access: yesQuarterly of Applied Mathematics, 1977
The investigation reported is concerned with the construction of the resolvent for any given kernel function. In problems with ill-behaved inhomogeneous terms as, for instance, in the aerodynamic problem of flow over a flapped airfoil, direct numerical methods become very difficult. A description is presented of a solution method by resolvent which can
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

EXISTENCE OF SOLUTIONS OF FRACTIONAL INTEGRODIFFERENTIAL SYSTEM WITH NONLOCAL CONDITIONS

open access: yesInternational Islamic University Malaysia Engineering Journal, 2015
:  In the present paper we prove the existence and uniqueness of local solutions of a nonlocal Cauchy problem for a class of fractional integrodifferential equation.
Kamlendra Kumar, Rakesh kumar
doaj   +1 more source

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