Results 111 to 120 of about 567,762 (287)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Global Hypoellipticity and Compactness of Resolvent for Fokker-Planck Operator [PDF]

open access: yes, 2009
22 pagesIn this paper we study the Fokker-Planck operator with potential $V(x),$ and analyze some kind of conditions imposed on the potential to ensure the validity of global hypoelliptic estimates.
Li, Wei-Xi
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The Classical Geometry of Chaotic Green Functions and Wigner Functions

open access: yesPhysics
Semiclassical (SC) approximations for various representations of a quantum state are constructed on a single (Lagrangian) surface in the phase space but such surface is not available for chaotic systems.
Alfredo M. Ozorio de Almeida
doaj   +1 more source

The Resolvent Operator of Singular Impulsive Dynamic Dirac Equations [PDF]

open access: yes
In this study, impulsive singular dynamic Dirac equations are considered. Firstly, a spectral function for these equations is constructed.
Allahverdiev, Bilender P.   +2 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Dichotomy and H^infinity functional calculi

open access: yesElectronic Journal of Differential Equations, 1995
densely defined closed operator on a Banach space is studied. We give conditions under which an operator with an $H^infty$ functional calculus has dichotomy.
R. DeLaubenfels, Y. Latushkin
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Hill's equation for a homogeneous tree

open access: yesElectronic Journal of Differential Equations, 1997
The analysis of Hill's operator $-D^2 + q(x)$ for $q$ even and periodic is extended from the real line to homogeneous trees ${cal T}$. Generalizing the classical problem, a detailed analysis of Hill's equation and its related operator theory on $L^2({cal
Robert Carlson
doaj  

Quaternionic resolvent equation and series expansion of the $\mathcal{S}$-resolvent operator

open access: yes
In the present paper, we prove a resolvent equation for the $\mathcal{S}$-resolvent operator in the quaternionic framework. Exploiting this resolvent equation, we find a series expansion for the $\mathcal{S}$-resolvent operator in an open neighborhood of
Ghiloni, Riccardo, Recupero, Vincenzo
core  

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