Results 121 to 130 of about 457,280 (245)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Global Hypoellipticity and Compactness of Resolvent for Fokker-Planck Operator
, 2009 22 pagesIn this paper we study the Fokker-Planck operator with potential $V(x),$ and analyze some kind of conditions imposed on the potential to ensure the validity of global hypoelliptic estimates.
Li, Wei-Xi
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Resolvent of the parallel composition and proximity operator of the infimal postcomposition
, 2022 In this paper we provide the resolvent computation of the parallel composition of a maximally monotone operator by a linear operator under mild assumptions. Connections with a modification of the warped resolvent are provided.
Roldán, Fernando, Briceño-Arias, Luis
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ON THE RESOLVENT OF SOME CLASS OF GENERALIZED DIFFERENTIAL OPERATOR
Advanced Engineering Research, 2006 In the article is given representation of the resolvent for generalized differential operator with generating function in the space of holomorphic functions.
A.V. BRATISHCHEV, A.V. MORZHAKOV
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Quaternionic resolvent equation and series expansion of the $\mathcal{S}$-resolvent operator
In the present paper, we prove a resolvent equation for the $\mathcal{S}$-resolvent operator in the quaternionic framework. Exploiting this resolvent equation, we find a series expansion for the $\mathcal{S}$-resolvent operator in an open neighborhood of
Ghiloni, Riccardo, Recupero, Vincenzo
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source