Results 151 to 160 of about 1,344,795 (373)

A comparison theorem for operators with compact resolvent [PDF]

open access: yesProceedings of the American Mathematical Society, 1971
The asymptotic behavior of the eigenvalue sequence of a semibounded operator with compact resolvent is stable under relatively bounded perturbations.
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The resolvent of a singularly perturbed elliptic operator

open access: yesJournal of Mathematical Analysis and Applications, 1977
AbstractLet A and B be uniformly elliptic operators of orders 2m and 2n, respectively, m > n. We consider the Dirichlet problems for the equations (ϵ2(m − n)A + B + λ2nI)uϵ = f and (B + λ2nI)u = f in a bounded domain Ω in Rk with a smooth boundary ∂Ω. The estimate ∥ uϵ − u ∥L2(Ω) ⩽ Cϵ ¦ λ ¦−2n + 1(1 + ϵ ¦ λ ¦)−1 ∥ f ∥L2(Ω) is derived.
Zeev Schuss, Zeev Schuss
openaire   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

On the generalized resolvents of isometric operators with gaps [PDF]

open access: yesarXiv, 2012
In this paper we obtain some slight correction and generalization of the results of Ryabtseva on the generalized resolvents for isometric operators with a gap in their spectrum. Also, analogs of some McKelvey's results and a short proof of Inin's formula for the generalized resolvents of an isometric operator are obtained.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Trace expansions for elliptic cone operators with stationary domains

open access: yes, 2009
We analyze the behavior of the trace of the resolvent of an elliptic cone differential operator as the spectral parameter tends to infinity. The resolvent splits into two components, one associated with the minimal extension of the operator, and another,
Gil, Juan B.   +2 more
core   +1 more source

On $L^p$ resolvent estimates for elliptic operators on compact manifolds [PDF]

open access: yesarXiv, 2013
We prove uniform $L^p$ estimates for resolvents of higher order elliptic self-adjoint differential operators on compact manifolds without boundary, generalizing a corresponding resul of [3] in the case of Laplace-- Beltrami operators on Riemannian manifolds. In doing so, we follow the methods, developed in [1] very closely.
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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