Results 81 to 90 of about 31,293 (331)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Local elliptic regularity for solutions to stationary Fokker–Planck equations via Dirichlet forms and resolvents

Boundary Value Problems
In this paper, we show that, for a solution to the stationary Fokker–Planck equation with general coefficients, defined as a measure with an L 2 $L^{2}$ -density, this density not only exhibits H 1 , 2 $H^{1,2}$ -regularity but also Hölder continuity. To
Haesung Lee
doaj   +1 more source

Asymptotic behaviour of mild solution of nonlinear stochastic partial functional equations

Nonlinear Analysis, 2019
This paper presents conditions to assure existence, uniqueness and stability for impulsive neutral stochastic integrodifferential equations with delay driven by Rosenblatt process and Poisson jumps.
Mamadou Abdoul Diop, Amour Toffodji Gbaguidi Amoussou, Carlos Ogouyandjou, Rathinasamy Sakthivel   +3 more
doaj   +1 more source

On Discontinuous Dirac Operator with Eigenparameter Dependent Boundary and Two Transmission Conditions [PDF]

, 2014
In this paper, we consider a discontinuous Dirac operator with eigenparameter dependent both boundary and two transmission conditions. We introduce a suitable Hilbert space formulation and get some properties of eigenvalues and eigenfunctions.
Güldü, Yalçın
core  

Some Resolvent Estimates for Sturm Liouville Operators

Journal of Mathematical Analysis and Applications, 1996
Using a method similar to the second author's [\textit{E. Mourre}, Commun. Math. Phys. 78, No. 3, 391-408 (1981; Zbl 0489.47010)], the authors obtain some estimates on the resolvent of the 1-D Schrödinger operator. Under certain conditions these estimates are used to show that the Schrödinger operator has a purely absolutely continuous spectrum.
Briet, P., Mourre, E.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Nonlinear ordered variational inclusion problem involving XOR operation with fuzzy mappings

Journal of Inequalities and Applications, 2020
In the setting of real ordered positive Hilbert spaces, a nonlinear fuzzy ordered variational inclusion problem with its corresponding nonlinear fuzzy ordered resolvent equation problem involving XOR operation has been recommended and solved by employing
Iqbal Ahmad, Syed Shakaib Irfan, Mohammad Farid, Preeti Shukla   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Entanglement of a chiral scalar on the torus

Journal of High Energy Physics
We compute the entanglement entropy of an interval for a chiral scalar on a circle at an arbitrary temperature. We use the resolvent method, which involves expressing the entropy in terms of the resolvent of a certain operator, and we compute that ...
Nicolás Abate, David Blanco, Alan Garbarz, Mateo Koifman, Guillem Pérez-Nadal   +4 more
doaj   +1 more source

Generalized Yosida Approximations Based on Relatively A-Maximal m-Relaxed Monotonicity Frameworks

Abstract and Applied Analysis, 2013
We introduce and study a new notion of relatively A-maximal m-relaxed monotonicity framework and discuss some properties of a new class of generalized relatively resolvent operator associated with the relatively A-maximal m-relaxed monotone operator and ...
Heng-you Lan
doaj   +1 more source