Results 81 to 90 of about 567,762 (287)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Resolvent estimates for scalar fields with electromagnetic perturbation

Electronic Journal of Differential Equations, 2004
In this note we prove some estimates for the resolvent of the operator $-Delta$ perturbed by the differential operator $$ V(x,D)=ia(x)cdot abla+V(x)quad hbox{in }mathbb{R}^3,.
Mirko Tarulli
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

On a Functional Equation Associated with (a,k)-Regularized Resolvent Families

Abstract and Applied Analysis, 2012
Let a∈Lloc1(ℝ+) and k∈C(ℝ+) be given. In this paper, we study the functional equation R(s)(a*R)(t)-(a*R)(s)R(t)=k(s)(a*R)(t)-k(t)(a*R)(s), for bounded operator valued functions R(t) defined on the positive real line ℝ+.
Carlos Lizama, Felipe Poblete
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Krein's resolvent formula and perturbation theory [Elektronisk resurs]

, 2004
The difference between the resolvents of two selfadjoint extensions of a certain symmetric operator A is described by Krein's resolvent formula. We will prove an analog of Krein's formula in a general framework, apply it to extensions theory, and give a ...
Kuroda, S T, Lund University., Kurasov, Pavel,   +2 more
core  

Resolvent operator theory of sequential quantum processes

, 1980
The Mower sequential decay theory of quantum processes has been extended in order formally to remove certain spurious poles in the matrix elements of the resolvent operator, and to recast the results into a more symmetrical general form. A special choice
Dalton B.J., Cresser J.D., B J Dalton, J D Cresser   +3 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source