Results 51 to 60 of about 76,730 (232)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

POVM Quantization

, 2014
We present a general formalism for giving a measure space paired with a separable Hilbert space a quantum version based on normalized positive operator-valued measure.
Gazeau, Jean Pierre, Heller, Barbara
core   +2 more sources

Three step algorithm for weighted resolvent average of a finite family of monotone operators

Filomat, 2018
In this paper, we introduce a composite iterative method for finding a common zero point of weighted resolvent average of a finite family of monotone operators. Furthermore, the strong convergence of the proposed iterative method is established. Finally, our results are illustrated by some numerical examples.
Bagheri, Malihe, Roohi, Mehdi
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Discrete spectra for critical Dirac-Coulomb Hamiltonians

, 2018
The one-particle Dirac Hamiltonian with Coulomb interaction is known to be realised, in a regime of large (critical) couplings, by an infinite multiplicity of distinct self-adjoint operators, including a distinguished, physically most natural one.
Gallone, Matteo, Michelangeli, Alessandro   +1 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Quantum Dynamics, Minkowski-Hilbert space, and A Quantum Stochastic Duhamel Principle [PDF]

, 2015
In this paper we shall re-visit the well-known Schr\"odinger and Lindblad dynamics of quantum mechanics. However, these equations may be realized as the consequence of a more general, underlying dynamical process.
Brown, Matthew F.
core  

On the $\mathcal{R}$-boundedness of solution operator families for two-phase Stokes resolvent equations

Differential and Integral Equations, 2017
The aim of this paper is to show the existence of $\mathcal{R}$-bounded solution operator families for two-phase Stokes resolvent equations in $\dotΩ=Ω_+\cupΩ_-$, where $Ω_\pm$ are uniform $W_r^{2-1/r}$ domains of $N$-dimensional Euclidean space $\mathbf{R}^N$ ($N\geq 2 ...
Maryani, Sri, Saito, Hirokazu
openaire   +3 more sources