Results 151 to 160 of about 8,830,736 (317)
On minimal doubly resolving sets in graphs
, 2021 Two vertices u,v of connected graph G are doubly resolved by x,y\in V(G)if d(v; x)-d(u; x)\neq d(v; y)-d(u; y): A set W of vertices of the graph G is a doubly resolving set for G if every two distinct vertices of G are doubly resolved by some two vertices of W. (G) is the minimum cardinality of a doubly resolving set for the graph G.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Every group is the maximal subgroup of a naturally occurring free idempotent generated semigroup
, 2012 Gray and Ruskuc have shown that any group G occurs as the maximal subgroup of some free idempotent generated semigroup IG(E) on a biordered set of idempotents E, thus resolving a long standing open question.
Gould, Victoria, Yang, Dandan
core +1 more source
Generalized Set-Valued Variational Inclusions and Resolvent Equations
Journal of Mathematical Analysis and Applications, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Resolving sets for breaking symmetries of graphs
, 2014 This paper deals with the maximum value of the difference between the determining number and the metric dimension of a graph as a function of its order. Our technique requires to use locating-dominating sets, and perform an independent study on other functions related to these sets. Thus, we obtain lower and upper bounds on all these functions by means
Garijo Royo, Delia +2 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source