Results 71 to 80 of about 60,505 (275)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Resolvability of A-, CA- and PCA-sets in compacta

Topology and its Applications, 1997
For a cardinal \(\kappa\), a space \(X=(X,{\mathcal T})\) is said to be \(\kappa\)-resolvable if \({\mathcal P}(X)\) contains \(\kappa\)-many pairwise disjoint \(\mathcal T\)-dense sets; in this terminology, \(X\) is resolvable if \(X\) is 2-resolvable, and \(X\) is maximally resolvable if \(X\) is \(\Delta(X)\)-resolvable, where \(\Delta(X)=\min\{|U|:\
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The independent resolving number of a graph [PDF]

, 2003
summary:For an ordered set $W=\lbrace w_1, w_2, \dots , w_k\rbrace $ of vertices in a connected graph $G$ and a vertex $v$ of $G$, the code of $v$ with respect to $W$ is the $k$-vector \[ c_W(v) = (d(v, w_1), d(v, w_2), \dots , d(v, w_k) ). \] The set $W$
Zhang, P., Chartrand, G., Saenpholphat, V.   +2 more
core   +1 more source

Resolving Predictive Multiplicity for the Rashomon Set

Proceedings of the AAAI Conference on Artificial Intelligence
The existence of multiple, equally accurate models for a given predictive task leads to predictive multiplicity, where a ``Rashomon set'' of models achieve similar accuracy but diverge in their individual predictions. This inconsistency undermines trust in high-stakes applications where we want consistent predictions.
Parian Haghighat, Hadis Anahideh, Cynthia Rudin   +2 more
openaire   +2 more sources

Properties of Fuzzy Resolving Set

Turkish Journal of Computer and Mathematics Education (TURCOMAT), 2021
In a fuzzy graph , for a subset  of , the representation of  with respect to  in terms of strength of connectedness of vertices are distinct then  is called the fuzzy resolving set of . In this article, we discuss the properties of fuzzy resolving set and fuzzy resolving number.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Resolving sets and resolving several objects in the finite king grid [PDF]

, 2017
An l-resolving set of a graph G is a set of vertices that has a unique array of distances to all vertex sets of G with up to l elements. The smallest cardinality of such a set is called the l-set-metric dimension of G.
Hakanen, Anni
core