Results 51 to 60 of about 1,947,311 (293)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Nonlinear modeling of ELM mitigation with RMP on HL-2A

Nuclear Fusion
Nonlinear modeling of mitigation of the edge localized mode (ELM) with resonant magnetic perturbation (RMP) is performed for the HL-2A tokamak, utilizing the three-dimensional (3D) magnetohydrodynamic code JOREK.
L. Wang, G.Z. Hao, M. Becoulet, Y.Q. Liu, Y.H. Xu, J.Q. Li, P.F. Zheng, D. Hu, S.L. Hu, G.Q. Dong, S. Wang, X.X. He, T.F. Sun, G.T.A. Huijsmans, W.L. Zhong, the JOREK Team   +15 more
doaj   +1 more source

2D heat flux in ASDEX Upgrade L-Mode with magnetic perturbation

Nuclear Materials and Energy, 2017
Power exhaust is one of the major challenges for a future fusion device like ITER. Future devices are foreseen to operate in a regime that exhibits periodic outbursts of particles and energy, so called edge localised modes (ELMs).
M. Faitsch, B. Sieglin, T. Eich, A. Herrmann, W. Suttrop   +4 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Wave propagation, phase mixing and dissipation in Hall MHD [PDF]

, 2012
In this thesis the effect of the Hall term in the generalised Ohm’s law on Alfvén (shear) and fast wave propagation and dissipation in the ion cyclotron frequency range is investigated.
Threlfall, James W.
core   +2 more sources

Metrics and extrapolation of resonant magnetic perturbation thresholds for ELM suppression

Nuclear Fusion
This large database study of resonant magnetic perturbation (RMP) edge localized mode (ELM) suppression thresholds in the AUG, DIII-D, EAST, and KSTAR tokamaks details the key strengths and weaknesses of RMP metrics. The RMP ELM suppression database used
N.C. Logan, S.K. Kim, S.M. Yang, J.-K. Park, Q. Hu, N. Leuthold, C. Paz-Soldan, S. Gu, D. Weisberg, H. Wang, Y. Sun, P. Xie, G. Nina Montano, T. Wang, M.W. Kim, M. Willensdorfer, EUROfusion WPTE Team, the ASDEX Upgrade Team   +17 more
doaj   +1 more source

Transport and acceleration mechanism of fast ions during edge localized modes in ASDEX Upgrade

Nuclear Fusion, 2023
Observations of enhanced fast-ion losses during edge localized modes (ELMs) have been reported in the ASDEX Upgrade tokamak, revealing losses above the injection energy. This suggests that fast ions can be accelerated and lost due to the ELMs.
J.F. Rivero-Rodríguez, J. Galdon-Quiroga, J. Domínguez-Palacios, M. García-Muñoz, D. Garcia-Vallejo, J. Gonzalez-Martin, K.G. McClements, L. Sanchís, K. Särkimäki, A. Snicker, Y. Todo, L. Velarde, E. Viezzer, the ASDEX Upgrade Team   +13 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Resonant Absorption and Fluctuations via Hybrid Simulations on Coronal Loops. I. Plasma Multifluid Description

The Astrophysical Journal
We investigate the resonant absorption process of a combination of left- and right-hand polarized waves (with a fixed perturbation amplitude) in a plasma slab with linearly inhomogeneous particle densities.
Hugo A. Carril, Jaume Terradas, Roberto E. Navarro, Adolfo F. Viñas, Marcel Goossens   +4 more
doaj   +1 more source