Results 41 to 50 of about 1,922,886 (290)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Effect of resonant magnetic perturbations on zonal flows and ambient turbulence [PDF]

open access: yes, 2020
Introduction Resonant magnetic perturbations (RMPs) are used at TEXTOR, DIII-D and JET and discussed for ITER for an effective mitigation of edge localized ...
D Reiser   +3 more
core  

Trimpi Perturbations from Large Ionisation Enhancement Patches

open access: yes, 2000
A number of increasingly sophisticated and realistic models have been developed in order to investigate the interaction between sub-ionospherically propagating VLF waves and regions of enhanced electron density in the D-region caused by lightning induced
D. Nunn   +3 more
core   +2 more sources

Influence of the safety factor variation on exitation of resonant magnetic perturbation in TOKAMAK rotating edge plasmas

open access: yesEast European Journal of Physics, 2013
Recently the possibility of resonant excitation of pressure perturbation by external helical magnetic perturbations near the rotating plasma edge was shown taking into consideration the finite plasma conductivity.
Igor Pankratov   +3 more
doaj  

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Runaway electron losses enhanced by resonant magnetic perturbations

open access: yes, 2011
Disruptions in large tokamaks can lead to the generation of a relativistic runaway electronbeam that may cause serious damage to the first wall. To suppress the runaway beam the applicationof resonant magnetic perturbations (RMP) has been suggested.
Papp, Gergely,   +4 more
core   +1 more source

Quasi-mode evolution in a stochastic magnetic field

open access: yesNuclear Fusion
We present a multi-scale model of quasi-mode evolution in a stochastic magnetic field. The similarity between a quasi-mode and a ballooning mode enables us to address the challenges arising from the disparate geometries in the theories of ballooning ...
Mingyun Cao, P.H. Diamond
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Effects of edge-localized electron cyclotron current drive on edge-localized mode suppression by resonant magnetic perturbations in DIII-D

open access: yesNuclear Fusion
According to recent DIII-D experiments (Logan et al 2024 Nucl. Fusion 64 014003), injecting edge localized electron cyclotron current drive (ECCD) in the counter-plasma-current (counter- I _p ) direction reduces the n = 3 resonant magnetic perturbation ...
Q.M. Hu, N.C. Logan, Q. Yu, A. Bortolon
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

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