Results 131 to 140 of about 141,811 (315)

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

open access: yesAdvanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan   +16 more
wiley   +1 more source

Ultrasound imaging of cortical bone: cortex geometry and measurement of porosity based on wave speed for bone remodeling estimation [PDF]

open access: yesarXiv
Intracortical US imaging extends B-mode imaging into bone using a dedicated image reconstruction algorithm that corrects for refraction at the bone-soft tissue interfaces. It has shown promising results in a few healthy, predominantly young adults, providing anatomical images of the cortex (periosteal and endosteal surfaces) along with estimations of ...
arxiv  

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

open access: yesAdvanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou   +9 more
wiley   +1 more source

Nuclear Factor-κB Decoy Oligodeoxynucleotide Attenuates Cartilage Resorption In Vitro

open access: yesBioengineering
Background: Cartilage harvest and transplantation is a common surgery using costal, auricular, and septal cartilage for craniofacial reconstruction. However, absorption and warping of the cartilage grafts can occur due to inflammatory factors associated ...
Hitoshi Nemoto   +3 more
doaj   +1 more source

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

open access: yesAdvanced Science, EarlyView.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen   +6 more
wiley   +1 more source

Morphologies in‐between: The impact of the first steps on the human talus

open access: yesThe Anatomical Record, Volume 306, Issue 1, Page 124-142, January 2023., 2023
Abstract Objective The development of bipedalism is a very complex activity that contributes to shaping the anatomy of the foot. The talus, which starts ossifying in utero, may account for the developing stages from the late gestational phase onwards.
Carla Figus   +21 more
wiley   +1 more source

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