Results 91 to 100 of about 1,473,023 (294)

RDA, Resource Description and Access: the metamorphosis of cataloguing

, 2016
Rivista accademica di respiro internazionale, con lo scopo di valorizzare la ricerca italiana nel campo delle biblioteche e delle scienze dell’informazione.
Mauro Guerrini, Carlo Bianchini
openaire   +3 more sources

Resource Description and Access para descrição de dados de autoridade: contexto para os artistas da música

, 2023
Ana Carolina Simionato, Amanda Azevedo dos Santos   +1 more
openalex   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Connecting RDA and RDF: Linked Data for a Wide World of Connected Possibilities

Pennsylvania Libraries: Research & Practice, 2015
Libraries have struggled with connecting a plethora of content and the metadata stored in catalogs to patrons. Adding more value to catalogs, more tools for reference librarians, and enriched patron search, linked data is a means to connect more people ...
Ashleigh Faith, Michelle Chrzanowski
doaj   +1 more source

Indochinese bamboos: biodiversity informatics to assist the identification of “vernacular taxa” [PDF]

, 2010
Bamboo (Bambusoides – Gramineae) is one of the most important natural resource in Southeast Asia. However, bamboo identification has many difficulties.
Bich Loan Nguyen, Thi, Diep Thi, My Hanh, Nguyen, Ha Puong, Vignes Lebbe, Régine   +3 more
core   +1 more source

IVOA Recommendation: Simple Spectral Access Protocol Version 1.1

, 2012
The Simple Spectral Access (SSA) Protocol (SSAP) defines a uniform interface to remotely discover and access one dimensional spectra. SSA is a member of an integrated family of data access interfaces altogether comprising the Data Access Layer (DAL) of ...
Bonnarel, Francois, Budavari, Tamas, Busko, Ivo, Dolensky, Markus, group, the Data Access Layer working, McDowell, Jonathan, Micol, Alberto, Osuna, Pedro, Salgado, Jesus, Skoda, Petr, Thompson, Randy, Tody, Doug, Valdes, Frank   +12 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source