Results 121 to 130 of about 1,473,023 (294)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
دراسات: تقنين جديد لوصف المصادر وإتاحتها في البيئة الرقمية Resource Description and Access (RDA) [PDF]
, 2009 د. يسرية زايد
openalex +1 more source
The National Transport Data Framework [PDF]
, 2008 Report by Professor Peter Landshoff (Cambridge University) and Professor John Polak (Imperial College London) on a project for the Department for Transport.
Landshoff, Peter Vincent, Polak, John
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Dynamic and distributed adaptation of scalable multimedia content in a context-aware environment [PDF]
, 2006 C
Cazoulat, Renaud +8 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
RDA : Resource Description and Access
, 2007 Provides a progress report on the current project to produce a new English-language cataloguing code called Resource Description and Access that will replace Anglo American Cataloguing Rules (2nd ed.). RDA is scheduled for final publication in 2009.
openaire +1 more source
GRIDCC: Real-time workflow system [PDF]
, 2007 The Grid is a concept which allows the sharing of resources between distributed communities, allowing each to progress towards potentially different goals.
Akram, A +7 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source