Results 51 to 60 of about 316,293 (230)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Connecting RDA and RDF: Linked Data for a Wide World of Connected Possibilities
Pennsylvania Libraries: Research & Practice, 2015 Libraries have struggled with connecting a plethora of content and the metadata stored in catalogs to patrons. Adding more value to catalogs, more tools for reference librarians, and enriched patron search, linked data is a means to connect more people ...
Ashleigh Faith, Michelle Chrzanowski
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
JLIS.it, 2018 After a methodological introduction and a recap of the evolutionary steps of the two descriptive models, the article aims at underlining contact points and differences between the Resource Description and Access (RDA) guidelines and the conceptual model ...
Giorgia Di Marcantonio
doaj +6 more sources
An IoT Unified Access Platform for Heterogeneity Sensing Devices Based on Edge Computing
IEEE Access, 2019 With the rapid development of the Internet of Things (IoT), a large number of heterogeneous sensing devices are accessed in their proprietary ways to IoT applications, formed “silos” application mode. The growth of IoT applications has been
Lina Lan +3 more
doaj +1 more source
Extended Resource Specification Language Reference Manual for ARC versions 0.8 and above [PDF]
, 2013 Extended Resource Specification Language Reference Manual for ARC versions 0.8 and ...
Ould-Saada, Farid
core +1 more source