Results 111 to 120 of about 14,843,340 (373)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Using resource graphs to represent conceptual change

open access: yes, 2006
We introduce resource graphs, a representation of linked ideas used when reasoning about specific contexts in physics. Our model is consistent with previous descriptions of resources and coordination classes.
A. A. diSessa   +60 more
core   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

HUMAN RESOURCES MANAGEMENT AND THE COMPANY’S INNOVATION [PDF]

open access: yes
This paper analyses the relationship between innovation and human resource management (HRM), attempting to establish whether innovation determines the company’s human resource management or, conversely, human resource management influences the level of ...
Alexandra Perju, Marius-Dan Dalotă
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Establishing a resource center: A guide for organizations supporting community foundations [PDF]

open access: yes, 2003
Maintaining a resource center such as a library is a central tasks of an association to serve its members, though one of the first to be neglected. WINGS-CF commissioned this guide to assist organizations supporting community foundations to review and ...
Barbara Denemark Long
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Grey literature review code [PDF]

open access: yes
It is often assumed that grey literature is not peer reviewed or lacks standards of quality and rigour. While this is often incorrect, there is currently no standard way of indicating the kind of review process that has occurred.
Amanda Lawrence
core  

Decentralized fault-tolerant control of inland navigation networks: a challenge [PDF]

open access: yes, 2016
Inland waterways are large-scale networks used principally for navigation. Even if the transport planning is an important issue, the water resource management is a crucial point.
Blesa Izquierdo, Joaquim   +5 more
core  

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