Results 121 to 130 of about 14,843,340 (373)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

SciFinder

Journal of the Medical Library Association, 2018
SciFinder, a resource from the Chemical Abstracts Service (CAS), is a curated database of chemical and bibliographic information that covers several scientific and biomedical fields, with an emphasis on chemistry.
Stephen Walter Gabrielson
doaj   +1 more source

Peer Review #2 of "Unconscious priming shares a common resource pool with the manipulation subsystem (v0.1)"

, 2022
Xuechen Mao, An-Min Li, U Ansorge, W Kunde, M Kiefer, A Baddeley, B Bahrami, N Lavie, G Rees, R Bayramova, E Toffalini, M Bonato, M Grassi, F Bergstrm, J Eriksson, G Bodner, S Stalinski, M Capizzi, D Sanabria, Correa, M Chow, A Conway, M Chun, J Golomb, N Turk-Browne, M Cohen, P Cavanagh, M Chun, K Nakayama, S Dehaene, J Changeux, L Naccache, J Sackur, C Sergent, M Eimer, F Schlaghecken, R Engle, L Fabre, P Lemaire, J Grainger, F Faul, E Erdfelder, A Lang, A Buchner, D Fougnie, R Marois, D Glahn, J Kim, M Cohen, V Poutanen, S Therman, S Bava, T Van Erp, M Manninen, M Huttunen, J Lnnqvist, C Standertskjld-Nordenstam, T Cannon, J Geng, F Meng, C Wang, H Haponenko, A Li, S Hung, D Wu, S Shimojo, D Jolles, S Kleibeuker, S Rombouts, E Crone, F Kattner, M Kiefer, A Kiesel, W Kunde, J Hoffmann, W Klotz, O Neumann, W Klotz, P Wolff, F Meng, A Li, Y You, C Xie, E Miller, M Lundqvist, A Bastos, A Moors, J De Houwer, L Naccache, E Blandin, S Dehaene, A Ozimi, G Repov, M Perea, A Marcet, M Lozano, P Gomez, J Spinks, J Zhang, P Fox   +99 more
openalex   +2 more sources

Bear Paw Regional Greenway-Comte Property Easement [PDF]

, 2003
Bear-Paw Regional Greenways successfully completed the tasks as outlined in the grant application and award from the New Hampshire Estuaries Project as of August 31st, 2003 for the project titled: Natural Resource Mapping and Land Protection Technical ...
Zankel, Susan
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Resource Review—Using Qualtrics Core XM for Surveying Youth

, 2021
Jennifer E. Cushman, Miriah Russo Kelly, Maryann Fusco-Rollins, Ryan Faulkner   +3 more
openalex   +2 more sources

Approaches to the teaching of design : an engineering subject centre guide [PDF]

, 2009
This booklet seeks to provide a resource for all those with an interest in design, and the education and training of engineering students to carry out the design process.
Mclaren, Andrew
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source