Results 61 to 70 of about 3,069,753 (207)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

RESCON: Educational project scheduling software. [PDF]

In this article we discuss a freely downloadable educational software tool for illustrating project scheduling and project management concepts. The tool features exact and heuristic scheduling procedures and visualizes project networks, project schedules,
Deblaere, Filip, Herroelen, Willy, Demeulemeester, Erik   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Job scheduling reservations on cloud resources

IJAIN (International Journal of Advances in Intelligent Informatics)
The current application of cloud computing focuses more on research problems. One of the main problems in the cloud is job allocation. Jobs are dynamically allocated to server processors. All cloud virtualized hardware is available to users on demand and
Ardi Pujiyanta, Fiftin Noviyanto
doaj   +1 more source

Customized Container Scheduling Strategy Based on GMM [PDF]

Jisuanji kexue
In cloud computing environments,as the number and types of containers continue to increase,resource management and scheduling complexity are increased.How to effectively schedule containers and optimize resource utilization and cluster perfor-mance has ...
ZHOU Kai, WANG Kai, ZHU Yuhang, PU Liming, LIU Shuxin, ZHOU Deqiang
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Data-Driven Evolutionary Resource Allocation for Vehicle–UAV Collaborative Inspection with Path-Scheduling Feedback

Technologies
To address the challenges of strong coupling between resource allocation and collaborative scheduling in vehicle–UAV cooperative inspections of power distribution lines, as well as the difficulty in balancing efficiency and stability, this paper proposes
Kunxiao Wu, Jianyong Zheng, Yuting Ding, Xiaoyi Liu, Yuhan Yin   +4 more
doaj   +1 more source

Exact and suboptimal reactive strategies for resource-constrained project scheduling with uncertain resource availabilities. [PDF]

In order to cope with the uncertainty inherent in practical project management, proactive and/or reactive strategies can be used. Proactive strategies try to anticipate future disruptions by incorporating slack time or excess resource availability into ...
Lambrechts, Olivier, Herroelen, Willy, Demeulemeester, Erik   +2 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Adaptive scheduling strategy for cloud computing resources based on Q-learning algorithm

Mechanics & Industry
Given the frequently varying loads of virtual machines and swift variations in resource demand in a cloud computing environment, this article introduces an adaptive resource scheduling strategy model based on Q-learning.
Xu Jiaxing, Gao Xiaofei, Gao Ningyuan
doaj   +1 more source