Results 61 to 70 of about 55,240 (258)

Resource Scheduling in ORCA for Next-Generation Mobile Networks: A Survey and Future Outlook

IEEE Access
The immense growth of mobile and IoT traffic is pushing the surging data demand beyond the traditional mobile network architectures towards a new domain of architectures, i.e., converged optical and radio networks (ORCA).
Sandra Arnaout, Md Arifur Rahman, Md Munjure Mowla, Adam Flizikowski, Slawomir Hausman, Piotr Korbel, Zoran Vujicic   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Adaptive scheduling strategy for cloud computing resources based on Q-learning algorithm

Mechanics & Industry
Given the frequently varying loads of virtual machines and swift variations in resource demand in a cloud computing environment, this article introduces an adaptive resource scheduling strategy model based on Q-learning.
Xu Jiaxing, Gao Xiaofei, Gao Ningyuan
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Customized Container Scheduling Strategy Based on GMM [PDF]

Jisuanji kexue
In cloud computing environments,as the number and types of containers continue to increase,resource management and scheduling complexity are increased.How to effectively schedule containers and optimize resource utilization and cluster perfor-mance has ...
ZHOU Kai, WANG Kai, ZHU Yuhang, PU Liming, LIU Shuxin, ZHOU Deqiang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Data-Driven Evolutionary Resource Allocation for Vehicle–UAV Collaborative Inspection with Path-Scheduling Feedback

Technologies
To address the challenges of strong coupling between resource allocation and collaborative scheduling in vehicle–UAV cooperative inspections of power distribution lines, as well as the difficulty in balancing efficiency and stability, this paper proposes
Kunxiao Wu, Jianyong Zheng, Yuting Ding, Xiaoyi Liu, Yuhan Yin   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

On Resource Efficiency of Workflow Schedules

Procedia Computer Science, 2014
AbstractThis paper presents the Maximum Effective Reduction (MER) algorithm, which optimizes the resource efficiency of a workflow schedule generated by any particular scheduling algorithm. The inefficiency in resource usage of workflow execution/schedule is not only in the number of resources used, but also the actual amount of “used” resource time ...
Young Choon Lee, Hyuck Han, Albert Y. Zomaya   +2 more
openaire   +1 more source