Results 81 to 90 of about 3,113,572 (297)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
New benchmark results for the resource-constrained project scheduling problem. [PDF]
This paper reports on computational results obtained with an updated version of the branch-and-bound procedure previously developed by Demeulemeester and Herroelen (1992) for solving the resource-constrained project scheduling problem (RCPSP).
Herroelen, Willy, Demeulemeester, Erik
core
Adaptive scheduling strategy for cloud computing resources based on Q-learning algorithm
Mechanics & IndustryGiven the frequently varying loads of virtual machines and swift variations in resource demand in a cloud computing environment, this article introduces an adaptive resource scheduling strategy model based on Q-learning.
Xu Jiaxing, Gao Xiaofei, Gao Ningyuan
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
On Resource Efficiency of Workflow Schedules
Procedia Computer Science, 2014 AbstractThis paper presents the Maximum Effective Reduction (MER) algorithm, which optimizes the resource efficiency of a workflow schedule generated by any particular scheduling algorithm. The inefficiency in resource usage of workflow execution/schedule is not only in the number of resources used, but also the actual amount of “used” resource time ...
Young Choon Lee +2 more
openaire +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Resource-constrained project scheduling for timely project completion with stochastic activity durations. [PDF]
We investigate resource-constrained project scheduling with stochastic activity durations. Various objective functions related to timely project completion are examined, as well as the correlation between these objectives. We develop a GRASP-heuristic to
Leus, Roel, Ballestin, F.
core
The Airfield Resource Scheduling Problem-Part Ⅱ:Development Status and Trends
Hangkong gongcheng jinzhan, 2019 Maximizing the utilization and benefit of airport resource has become a common goal of air transport stakeholders, including air navigation service providers, airports, airlines, passengers and governments.This work focuses on the development status and ...
Yin Jianan, Ma Yuanyuan, Hu Minghua
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
RESCON: Educational project scheduling software. [PDF]
In this article we discuss a freely downloadable educational software tool for illustrating project scheduling and project management concepts. The tool features exact and heuristic scheduling procedures and visualizes project networks, project schedules,
Deblaere, Filip +2 more
core