Results 51 to 60 of about 3,186,017 (302)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The energy scheduling problem: Industrial case-study and constraint propagation techniques [PDF]
, 2013 This paper deals with production scheduling involving energy constraints, typically electrical energy. We start by an industrial case-study for which we propose a two-step integer/constraint programming method.
Pierre Lopez +5 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Servitization of Job Shop Scheduling Algorithms
Journal of Harbin University of Science and Technology, 2018 The scheduling algorithm resources are not yet fully shared betwwen manufacturing execution system, and it is difficult to efficiently select the appropriate scheduling algorithm for scheduling problem from the candidate scheduling resources. To resolve
LIU Sheng-hui +3 more
doaj +1 more source
A novel class of scheduling policies for the stochastic resource-constrained project scheduling problem. [PDF]
We study the resource-constrained project scheduling problem with stochastic activity durations. We introduce a new class of scheduling policies for this problem, which make a number of a-priori sequencing decisions in a pre-processing phase, while the ...
Leus, Roel +2 more
core
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Machine Scheduling with Resource Dependent Processing Times [PDF]
We consider several parallel machine scheduling settings with the objective to minimize the schedule makespan. The most general of these settings is unrelated parallel machine scheduling.
Sviridenko,Maxim +2 more
core
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Resource-constrained project scheduling. [PDF]
: Resource-constrained project scheduling involves the scheduling of project activities subject to precedence and resource constraints in order to meet the objective(s) in the best possible way. The area covers a wide variety of problem types.
Herroelen, Willy, Demeulemeester, Erik
core