Results 121 to 130 of about 3,112,923 (297)

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

A branch-and-bound procedure for the resource-constrained project scheduling problem with generalized precedence relations. [PDF]

open access: yes
We present an optimal procedure for the resource-constrained project scheduling problem (RCPSP) with generalized precedence relations (further denoted as RCPSP-GPR) with the objective of minimizing the project makespan. The RCPSP-GPR extends the RCPSP to
De Reyck, B, Herroelen, Willy
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

Timeslack-based techniques for generating robust projectschedules subject to resource uncertainty. [PDF]

open access: yes
The classical, deterministic resource-constrained project scheduling problem has been the subject of a great deal of research during the previous decades. This is not surprising given the high practical relevance of this scheduling problem. Nevertheless,
Lambrechts, Olivier   +2 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

An investigation of resource-allocation decisions by means of project networks. [PDF]

open access: yes
This paper investigates the relationship between resource allocation and ES-policies, which are a type of scheduling policies introduced for stochastic scheduling and which can be represented by a directed acyclic graph.
Leus, Roel
core  

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