Results 81 to 90 of about 3,112,923 (297)
A survey of variants and extensions of the resource-constrained project scheduling problem [PDF]
The resource-constrained project scheduling problem (RCPSP) consists of activities that must be scheduled subject to precedence and resource constraints such that the makespan is minimized.
Hartmann, Sönke, Briskorn, Dirk
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Exact and suboptimal reactive strategies for resource-constrained project scheduling with uncertain resource availabilities. [PDF]
In order to cope with the uncertainty inherent in practical project management, proactive and/or reactive strategies can be used. Proactive strategies try to anticipate future disruptions by incorporating slack time or excess resource availability into ...
Lambrechts, Olivier +2 more
core
The trade-off between stability and makespan in resource-constrained project scheduling. [PDF]
During the last decade a lot of research efforts in the project scheduling literature have concentrated on resource-constrained project scheduling under uncertainty.
Herroelen, Willy +3 more
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Proactive resource allocation heuristics for robust project scheduling. [PDF]
The well-known deterministic resource-constrained project scheduling problem (RCPSP) involves the determination of a predictive schedule (baseline schedule or pre-schedule) of the project activities that satisfies the finish-start precedence relations ...
Braeckmans, Kristof +3 more
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
New benchmark results for the resource-constrained project scheduling problem. [PDF]
This paper reports on computational results obtained with an updated version of the branch-and-bound procedure previously developed by Demeulemeester and Herroelen (1992) for solving the resource-constrained project scheduling problem (RCPSP).
Herroelen, Willy, Demeulemeester, Erik
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source