Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
A hybrid scatter search. Electromagnetism meta-heuristic for project scheduling. [PDF]
In the last few decades, several effective algorithms for solving the resource-constrained project scheduling problem have been proposed. However, the challenging nature of this problem, summarised in its strongly NP-hard status, restricts the ...
Debels, D +3 more
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Design and Application of Vague Set Theory and Adaptive Grid Particle Swarm Optimization Algorithm in Resource Scheduling Optimization. [PDF]
J Grid Comput, 2023 Han Y +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
A classification of predictive-reactive project scheduling procedures. [PDF]
The vast majority of the project scheduling research efforts over the past several years have concentrated on the development of workable predictive baseline schedules, assuming complete information and a static and deterministic environment.
Herroelen, Willy +2 more
core
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Algorithms for scheduling projects with generalized precedence relations. [PDF]
Project scheduling under the assumption of renewable resource constraints and generalized precedence relations, i.e. arbitrary minimal and maximal time lags between the starting and completion times of the activities of the project, constitutes an ...
De Reyck, B +2 more
core
Deep Q networks-based optimization of emergency resource scheduling for urban public health events. [PDF]
Neural Comput Appl, 2023 Zhao X, Wang G.
europepmc +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Computational experience with a branch-and-bound procedure for the resource-constrained project scheduling problem with generalized precedence relations. [PDF]
In a previous paper (De Reyck and Herroelen, 1996a), we presented an optimal procedure for the resource-constrained project scheduling problem (RCPSP) with generalised precedence relations (further denoted as RCPSP-GPR) with the objective of minimizing ...
De Reyck, B, Herroelen, Willy
core