Results 71 to 80 of about 3,113,572 (297)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A survey of variants and extensions of the resource-constrained project scheduling problem [PDF]

The resource-constrained project scheduling problem (RCPSP) consists of activities that must be scheduled subject to precedence and resource constraints such that the makespan is minimized.
Hartmann, Sönke, Briskorn, Dirk
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Exact and suboptimal reactive strategies for resource-constrained project scheduling with uncertain resource availabilities. [PDF]

In order to cope with the uncertainty inherent in practical project management, proactive and/or reactive strategies can be used. Proactive strategies try to anticipate future disruptions by incorporating slack time or excess resource availability into ...
Lambrechts, Olivier, Herroelen, Willy, Demeulemeester, Erik   +2 more
core  

The trade-off between stability and makespan in resource-constrained project scheduling. [PDF]

During the last decade a lot of research efforts in the project scheduling literature have concentrated on resource-constrained project scheduling under uncertainty.
Herroelen, Willy, Van de Vonder, Stijn, Demeulemeester, Erik, Leus, Roel   +3 more
core   +2 more sources

Job scheduling reservations on cloud resources

IJAIN (International Journal of Advances in Intelligent Informatics)
The current application of cloud computing focuses more on research problems. One of the main problems in the cloud is job allocation. Jobs are dynamically allocated to server processors. All cloud virtualized hardware is available to users on demand and
Ardi Pujiyanta, Fiftin Noviyanto
doaj   +1 more source

Customized Container Scheduling Strategy Based on GMM [PDF]

Jisuanji kexue
In cloud computing environments,as the number and types of containers continue to increase,resource management and scheduling complexity are increased.How to effectively schedule containers and optimize resource utilization and cluster perfor-mance has ...
ZHOU Kai, WANG Kai, ZHU Yuhang, PU Liming, LIU Shuxin, ZHOU Deqiang
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Proactive resource allocation heuristics for robust project scheduling. [PDF]

The well-known deterministic resource-constrained project scheduling problem (RCPSP) involves the determination of a predictive schedule (baseline schedule or pre-schedule) of the project activities that satisfies the finish-start precedence relations ...
Braeckmans, Kristof, Herroelen, Willy, Demeulemeester, Erik, Leus, Roel   +3 more
core  

Data-Driven Evolutionary Resource Allocation for Vehicle–UAV Collaborative Inspection with Path-Scheduling Feedback

Technologies
To address the challenges of strong coupling between resource allocation and collaborative scheduling in vehicle–UAV cooperative inspections of power distribution lines, as well as the difficulty in balancing efficiency and stability, this paper proposes
Kunxiao Wu, Jianyong Zheng, Yuting Ding, Xiaoyi Liu, Yuhan Yin   +4 more
doaj   +1 more source