Results 81 to 90 of about 79,637 (307)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Exact and suboptimal reactive strategies for resource-constrained project scheduling with uncertain resource availabilities. [PDF]

In order to cope with the uncertainty inherent in practical project management, proactive and/or reactive strategies can be used. Proactive strategies try to anticipate future disruptions by incorporating slack time or excess resource availability into ...
Lambrechts, Olivier, Herroelen, Willy, Demeulemeester, Erik   +2 more
core  

The trade-off between stability and makespan in resource-constrained project scheduling. [PDF]

During the last decade a lot of research efforts in the project scheduling literature have concentrated on resource-constrained project scheduling under uncertainty.
Herroelen, Willy, Van de Vonder, Stijn, Demeulemeester, Erik, Leus, Roel   +3 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

New benchmark results for the resource-constrained project scheduling problem. [PDF]

This paper reports on computational results obtained with an updated version of the branch-and-bound procedure previously developed by Demeulemeester and Herroelen (1992) for solving the resource-constrained project scheduling problem (RCPSP).
Herroelen, Willy, Demeulemeester, Erik
core  

Adaptive scheduling strategy for cloud computing resources based on Q-learning algorithm

Mechanics & Industry
Given the frequently varying loads of virtual machines and swift variations in resource demand in a cloud computing environment, this article introduces an adaptive resource scheduling strategy model based on Q-learning.
Xu Jiaxing, Gao Xiaofei, Gao Ningyuan
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Resource-constrained project scheduling for timely project completion with stochastic activity durations. [PDF]

We investigate resource-constrained project scheduling with stochastic activity durations. Various objective functions related to timely project completion are examined, as well as the correlation between these objectives. We develop a GRASP-heuristic to
Leus, Roel, Ballestin, F.
core  

The energy scheduling problem: Industrial case-study and constraint propagation techniques [PDF]

, 2013
This paper deals with production scheduling involving energy constraints, typically electrical energy. We start by an industrial case-study for which we propose a two-step integer/constraint programming method.
Pierre Lopez, Lopez, Pierre, Artigues, Christian, Christian Artigues, Haït, Alain, Alain Haït   +5 more
core   +1 more source