Results 71 to 80 of about 431,343 (275)
IEEE AccessCloud computing has become a revolutionary model for providing computational resources and services via the internet. As the volume of tasks and the dynamic nature of cloud resources increase, several critical challenges emerge, including load balancing,
Olanrewaju L. Abraham +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Job scheduling reservations on cloud resources
IJAIN (International Journal of Advances in Intelligent Informatics)The current application of cloud computing focuses more on research problems. One of the main problems in the cloud is job allocation. Jobs are dynamically allocated to server processors. All cloud virtualized hardware is available to users on demand and
Ardi Pujiyanta, Fiftin Noviyanto
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Exact and heuristic reactive planning procedures for multi-mode resource-constrained projects. [PDF]
The multi-mode resource-constrained project scheduling problem (MRCPSP) involves the determination of a baseline schedule of the project activities, which can be executed in multiple modes, satisfying the precedence relations and resource constraints ...
Deblaere, Filip +2 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
SLS-PLAN-IT: A knowledge-based blackboard scheduling system for Spacelab life sciences missions [PDF]
The primary scheduling tool in use during the Spacelab Life Science (SLS-1) planning phase was the operations research (OR) based, tabular form Experiment Scheduling System (ESS) developed by NASA Marshall.
Kao, Cheng-Yan, Lee, Seok-Hua
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Trust-aware dynamic level scheduling algorithm in cloud environment
Tongxin xuebao, 2014 Based on interpersonal trust model in sociology，a trust evaluation model is proposed based on users’ past experience with service provider，friends’ recommendations and third party’s feedback.By combining users’ trust requirement for service resource ...
Jie CAO +3 more
doaj +2 more sources
An investigation of resource-allocation decisions by means of project networks. [PDF]
This paper investigates the relationship between resource allocation and ES-policies, which are a type of scheduling policies introduced for stochastic scheduling and which can be represented by a directed acyclic graph.
Leus, Roel
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