Results 101 to 110 of about 2,284,877 (259)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Avian Conservation and EcologyThe San Luis Valley (SLV), Colorado is a critical stopover area for Rocky Mountain Population greater Sandhill Cranes ( Antigone canadensis tabida ). During spring and autumn, cranes use crops for foraging and water resources adjacent to foraging areas ...
Rachel A Vanausdall +4 more
doaj +1 more source
Ranging ecology and resource selection of white-lipped peccaries (Tayassu pecari) in the world's largest tropical agricultural frontier. [PDF]
Ecol Evol, 2023 Costa HCM +5 more
europepmc +1 more source
Methods and techniques specific to human resource management [PDF]
The first part of the study presents the contextual and conceptual novelty elements concerning human resources on which this human resource management approach relies.
Ovidiu NICOLESCU
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
EcosphereHabitat loss and fragmentation are a growing threat to wildlife, and a better understanding of these landscape processes is needed to mitigate their effects on species populations.
Sprih Harsh +3 more
doaj +1 more source
FishesIndonesia is home to significant populations of globally vulnerable reef manta rays (Mobula alfredi) in at least four key regions: Berau, Nusa Penida, Komodo, and Raja Ampat.
Edy Setyawan +10 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Methods in Ecology and EvolutionStep‐selection analysis (SSA) is ubiquitous for assessing local‐scale habitat selection by comparing relocations from telemetry data (used steps) to potential relocations given the movement of the animal (available steps).
Michael E. Egan +5 more
doaj +1 more source