Results 121 to 130 of about 1,558,704 (279)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Huckleberry Habitat and Its Influence on Two Small Populations of Grizzly Bears (Ursus arctos)

open access: yesEcology and Evolution
Huckleberries (Vaccinium spp.) are a nutritionally important food to grizzly bears (Ursus arctos) in interior, western North America. They provide sugar‐rich calories in late summer and fall prior to denning. We developed a resource selection function of
Justin E. Teisberg   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Resource selection by Sarda cattle in a Mediterranean silvopastoral system

open access: yesFrontiers in Veterinary Science
Knowledge of how grazing cattle utilize heterogeneous landscapes in Mediterranean silvopastoral areas is scarce. Global positioning systems (GPS) to track animals, together with geographic information systems (GIS), can relate animal distribution to ...
Marco Acciaro   +6 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

NFV Service Chain Resource Allocation Technology

open access: yesDianxin kexue, 2015
SDN/NFV provides supporting technologies on network re-architecture and evolution for network operator.Service chain and related networking technology is becoming a significant use case of NFV,of which resource allocation is one of the key research ...
Hong Tang, Yujia Luo
doaj   +2 more sources

The 4th Dimension in Animal Movement: The Effect of Temporal Resolution and Landscape Configuration in Habitat‐Selection Analyses

open access: yesEcology and Evolution
Understanding how animals use their habitat is essential to understand their biology and support conservation efforts. Technological advances in tracking technologies allow us to follow animals at increasingly fine temporal resolutions. Yet, how tracking
Johannes Signer   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

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