Results 61 to 70 of about 335,691 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Presence-only data, pseudo-absences, and other lies about habitat selection

open access: yesIdeas in Ecology and Evolution, 2010
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Mark S. Boyce
doaj  

Resource elasticity of offspring survival and the optimal evolution of sex ratios. [PDF]

open access: yesPLoS ONE, 2013
The fitness of any organisms includes the survival and reproductive rate of adults and the survival of their offspring. Environmental selection pressures might not affect these two aspects of an organism equally. Assuming that an organism first allocates
Rui-Wu Wang   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

K-fold cross-validation results for top resource selection function models.

open access: yes, 2013
K-fold cross-validation results for top resource selection function models.
David A. Yokel (300379)   +7 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Selecting habitat to what purpose? The advantage of exploring the habitat–fitness relationship

open access: yesEcosphere, 2017
Measures of reproductive success have been recognized in many fields as essential tools to assess the status of populations, species, and communities. However, difficulties in gathering data on reproductive success often prevent researchers from taking ...
Alessia Uboni   +3 more
doaj   +1 more source

Globalisation of the HR function level: exploring the issues through international recruitment, selection and assessment processes [PDF]

open access: yes, 2007
Much of the debate around convergence-divergence is based around comparative analysis of HR systems. However, we need now to combine these insights with work in the field of IHRM on firm-level motivations to optimise, standardise and export HR models ...
Sparrow, P R
core  

Appendix B. Environmental covariates used in resource selection function (RSF) modeling for mule deer.

open access: yes, 2016
Environmental covariates used in resource selection function (RSF) modeling for mule ...
Joseph M. Northrup (117628)   +3 more
core   +1 more source

Sex and flowers: testing the resource-dependent selection hypothesis for flower sex allocation [PDF]

open access: yes, 2022
Context: Monoecious plants can adjust their proportional investment in male and female flowers to maximise reproductive fitness. The female reproductive function (seeds) often has greater resource costs than the male (pollen). Larger plants are generally
Finch, Jonathan T.   +2 more
core   +1 more source

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