Results 121 to 130 of about 15,653,492 (359)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
FINANCING THE MILITARY HEALTH SYSTEM [PDF]
Annals: Series on Military Sciences, 2018 Health systems in EU Member States are funded through public contributions or direct contributions. Each Member State has developed its own funding mechanisms.
Gabriel COJOCARU
doaj
AN APPROACH TO THE PROBLEM OF COMMON POOL RESOURCES THROUGH AN EXTENSION OF THE EQUILIBRIUM CONCEPT [PDF]
, 2013 Jaegug Bae, Jong-Seok Kim, Eun Sook Kang
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Georgia's Taxes: A Summary of Major State and Local Government Taxes (Ninth Edition) [PDF]
, 2003 This annual publication is designed to give a quick overview of state and local taxes in Georgia, and comparisons with other ...
Jack Morton, Richard Hawkins
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Georgia Per Capita Income: Indentifying the Factors Contributing to the Growing Income Gap with Other States - Brief [PDF]
, 2009 This report explores why Georgia's per capita personal income growth over the past decade has been slow, resulting in Georgia being ranked 50th in the nation in per capita income growth.
Sean Turner
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source