Results 131 to 140 of about 2,301,842 (265)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases. [PDF]

Nat Genet
Zhao Y, Strober B, Hou K, Kerner G, Danesh J, Gazal S, Cheng W, Inouye M, Price AL, Jiang X.   +9 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Exploring the moral status of cadavers through artificial intelligence: a thematic analysis of AI-based perspectives in anatomy education. [PDF]

Philos Ethics Humanit Med
Topcu I, Karip B, Demir P, Kac B.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mothers' responses to relational savoring as a function of attachment: A qualitative study. [PDF]

Infant Ment Health J
Marvin MJ, Smiley PA, Cervantes BR, Kerr ML, Borelli JL.   +4 more
europepmc   +1 more source

Respect the history

Indian Journal of Dermatology, 2015
openaire   +3 more sources

Tabaquismo: valores e integralidad

Revista Médica Electrónica
El tabaquismo constituye un problema de salud de gran magnitud a nivel mundial, y en Cuba muestra una tendencia al aumento de su incidencia, sobre todo, en las edades de la adolescencia y la juventud.
Avelino Plá García, Miriam Gloria Elizarde Gálvez, Evelio Cárdenas Friera, Juan Carlos Solares Carreño, Blanca Nieves Nieves Sardiñas   +4 more
doaj  

Completion of Treatment Escalation Plans and Resuscitation Discussions in Frail and Elderly Patients With Hip Fractures. [PDF]

Cureus
Stonelake H, Ashwood N.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source