Results 51 to 60 of about 7,633,470 (239)
To anticipate the future, models simulate US. pistachio prices
Models developed on U.S. pistachio production simulate grower prices under scenarios of varying import levels and carryover stocks. Grower prices have significantly varied for 13 years, partly because of changes in import levels and ...
Desmond Jolly, Kim Norris
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Nitrogen isotope ratios identify nitrate contamination sources
Nitrate contamination of groundwater is becoming a widespread problem in California. To evaluate the utility of stable nitrogen isotopes for identifying sources of nitrate contamination, nitrogen isotope ratios (?15N) were measured on nitrate extracted ...
Dennis Rolston +4 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Yam Production with or without Trellisingi
A 72 m2 area in Don Martin Marundan, Mati, Davao Oriental was planted to pre-treated and pre-sprouted yam setts arranged in a randomized complete block design to compare the tuber yield and costs when yams are grown with or without trellis.
Emma Ruth Bayogan, Necito Baldoz
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Cold ‘Brooks’ cherries suffer more pitting and bruising
The incidence of pitting and impact bruising on ‘Brooks’ sweet cherries was greatest when the flesh temperature was near 1 °C (34°F), intermediate near 10°C (50°F), and lowest near 20°C (68°F).
Carlos Crisosto +3 more
doaj +1 more source

