Results 141 to 150 of about 158,191 (301)

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

The Relationship between Respiratory Indexes with the Consequences of Weaning from Mechanical Ventilator in CABG Patients in ShahidRajaei Hospital, Tehran, Iran, 2011

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Weaning a patient from mechanical ventilator is a critical step in the process of treatment at CCU which takes a long time of mechanical ventilation.
Mitra Khoobi, Majid Ahmady Hedayat, Nooredin Mohammady, Mansooreh Ashghali Farahani, Hamid Haghani, Arash Anisiyan   +5 more
doaj  

Artificial Respiration at Sea [PDF]

BMJ, 1942
openaire   +3 more sources

The Mitochondrial Protein RESISTANCE to APHIDS 9 Interacts with S40 to Resist Aphid Infestation by Modulating Reactive Oxygen Species Homeostasis in Maize (Zea mays)

Advanced Science, EarlyView.
This study identifies the mitochondrial protein RTA9, a member of the Domain of Unknown Function 641 family, together with its partner S40, as key regulators of aphid resistance in maize. RTA9 promotes S40 degradation and modulates reactive oxygen species accumulation.
Chuanhong Wang, Xinqiao Zhang, Zhen Tao, Lei Wang, Shijie Huang, Tengyue Wang, Yibing Zhao, Jinghui Dong, Jing Ma, Chang Chang, Xingzhi Chen, Ning Lin, Peijin Li   +12 more
wiley   +1 more source

Ideas of I. M. Sechenov in aviation and space medicine [PDF]

The contributions I. M. Sechenov (19th century) made to modern physiology are described, including his studies on gases in the blood (O2 and CO2), and how these studies were the basic building blocks of current efforts in aviation and space medicine ...
Gazenko, O. G., Kovalenko, Y. A.
core   +1 more source

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

Methods of Artificial Respiration [PDF]

BMJ, 1943
openaire   +2 more sources

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source