Results 241 to 250 of about 3,346,625 (362)

Breathing mode selectively modulates brain-wide functional connectivity. [PDF]

PLoS One
Mohammadi S, Hossein-Zadeh GA, Raoufy MR.   +2 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Isn't it ironic? Functional iron deficiency at the core of Parkinson's disease pathobiology. [PDF]

J Clin Invest
Peikon I, Andrews NC.
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Impaired mitochondrial ketone body oxidation in insulin resistant states. [PDF]

EBioMedicine
Zweck E, Piel S, Schmidt JW, Scheiber D, Schön M, Kahl S, Burkart V, Dewidar B, Remus R, Chadt A, Al-Hasani H, Mastrototaro L, Aubin H, Boeken U, Lichtenberg A, Distler J, Polzin A, Kelm M, Westenfeld R, Wagner R, Schrauwen P, Szendroedi J, Roden M, Granata C.   +23 more
europepmc   +1 more source

Measurement of Mitochondrial Respiration and Motility in Acute Care

Journal of Intensive Care Medicine, 2017
D. Jang, J. Greenwood, M. Spyres, D. Eckmann   +3 more
semanticscholar   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Reply to: Altered effort and deconditioning are not valid explanations of myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

Nat Commun
Walitt B, Chin L, Drinkard B, Lamunion S, Brychta R, Chen K, Stussman B, Mammen A, Pinal Fernandez I, Snow J, Madian N, Hallett M, Nath A.   +12 more
europepmc   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Mitochondrial respiration in peripheral blood mononuclear cells of healthy adult population. [PDF]

PLoS One
Lee JH, Vine J, Balaji L, Peradze N, Antony N, Wang Y, Morton A, Moskowitz A, Donnino MW, Liu X.   +9 more
europepmc   +1 more source